- 期刊
- OpenAccess
Monotherapy with erythromycin results in severe rhabdomyolysis
並列摘要
Introduction: Rhabdomyolysis is a potentially life-threatening condition caused by muscle necrosis and extravasation of intracellular muscle contents into the blood circulation. An elevation in serum creatine kinease is most confirmatory laboratory test. Erythromycin is an inhibitor of the CYP_3A_4 enzyme system which is responsible for the metabolism of several drugs, particularly some statins. Although rhabdomyolysis asssociated with macrolid-statin interaction has been previously described, we report the first case of erythromycin-induced rhabdomyolysis. Case Report: In our case, a 38-year-old male admitted with pneumonia developed rhabdomyolysis associated with erythromycin administration. Conclusion: Clinicians need to be aware of the risks this potential adverse drug reaction poses.
延伸閱讀
- Chang, H. W., Wang, M. H., Kuo, C. C., & Wang, B. M. (2017). Thyrotoxic Periodic Paralysis with Rhabdomyolysis: A Case Report. Formosan Journal of Endocrinology and Metabolism, 8(2), 93-96. https://doi.org/10.6856/FJEM.201712_8(2).0008
- 葉德輝、李憲彥、林恒立（1993）。Clinical Trial of Roxithromycin in Upper Respiratory Tract Infection。中華民國耳鼻喉科醫學會雜誌，28(2)，123-127。https://doi.org/10.6286/1993.28.2.123
- Rosenn, M. F., Macones, G. A., & Silverman, N. S. (1995). Randomized Trial of Erythromycin and Azithromycin for Treatment of Chlamydial Infection in Pregnancy. Infectious Diseases in Obstetrics and Gynecology, 1995(), 241-244. https://doi.org/10.1155/S1064744995000718
- Wu, C. C., & Lin, Y. F. (2005). Rhabdomyolysis and Acute Renal Failure. Acta Nephrologica, 19(2), 53-55. https://www.airitilibrary.com/Article/Detail?DocID=10131671-200504-19-2-53-55-a
- Yildirim, Y., Kara, A. V., Yilmaz, Z., Bodakci, E., Demircan, V., Kadiroglu, A. K., & Yilmaz, M. E. (2015). A Rare Cause of Rhabdomyolysis: Gitelman Syndrome. International Journal of Case Reports and Images (IJCRI), 6(10), 618-621. https://doi.org/10.5348/ijcri-2015100-CR-10561