- 期刊
Epidemiologic Characteristics of Malignant Neoplasms in Taiwan: Ⅱ. Liver Cancer
台灣地區惡性腫瘤之流行病學特徵：Ⅱ肝癌
摘要
爲探討肝癌之年齡曲線、性比例、地理分佈、長期變動趨勢、國際比較及移民差異等流行病學特徵，乃以台灣地區1954至1983的肝癌死亡率及發生率爲資料來源。分析結果顯示台灣地區男性之肝癌的年齡標準化死亡率顯著的逐漸上升，女性則無明顯的變動趨勢存在。觀察各年齡層之肝癌死亡率在1954-1963，1964-1973及1974-1983三段連續期間的變動情形，發現1954-1963期間至1964-1973期間，不論男性或女性，所有年齡層的肝癌死亡率皆明顯的增加，但1964-1973期間至1974-1983期間，男性20-29歲的年齡層與女性大多數年齡層之肝癌死亡率反而呈現下降。國際比較和移民研究顯示中國人之肝癌死亡率遠高於其它種族，台灣地區男性與女性的肝癌累積死亡率分別爲4.83%和1.74%，在世界18個國家及地區中排名爲第二位，僅次於香港。肝癌死亡率的地理分佈在台灣地區呈現明顯的差異，高危險鄉鎮集中於澎湖群島、烏腳病流行地區和東部山區。本研究之觀察結果顯示除B型肝炎病毒以外，其它環境因子可能亦在肝癌的發展過程中具有相當重要的作用。
關鍵字
無資料並列摘要
Mortality and incidence rates of liver cancer were analyzed to examine the epidemiologic characteristics of the disease in Taiwan. A significant upward secular trend for age-adjusted mortality rates from 1954 to 1983 was observed in males but not in females. The mortality rate of liver cancer increased significantly for all the age groups during the interval between two periods of 1954-1963 and 1964-1973. However, the mortality rate decreased for the age group of 20-29 in males and for most age groups in females during the interval between two periods of 1964-1973 and 1974-1983. Both international comparison and migrant study indicated an extraordinarily high risk of liver cancer among Chinese than other populations throughout the world. The cumulative mortality rate of liver cancer was 4.83% and 1.74% for males and females, respectively. The cumulative rate in Taiwan ranked as the second among 18 selected countries and areas compared. Mortality rates of liver cancer in Taiwan were lower than those in Hong Kong and higher than those in Mainland China for most age groups in both males and females. Striking geographical variation of liver cancer mortality was observed in Taiwan with high risk areas clustered in the Penghu Islets, the blackfoot disease endemic area and eastern mountainous aboriginal townships. The observations suggest environmental risk factors in addition to hepatitis B virus infection may be involved in the development of liver cancer.
延伸閱讀
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