鐵缺乏性貧血對懷孕母鼠及胎兒發育之影響

Effect of Iron Deficiency Anemia on Pregnant Rat and Fetal Growth

賴愛姬(Ai-Chi Lai)

《中華民國營養學會雜誌》 14卷1&2期 (1989/04) Pp. 45-53

https://doi.org/10.6691/JCNS.198904_14(1_2).0005

摘要

Anemia is the most prevalent form of malnutrition and it occurs very often in the pregnancy and infancy especially. This study is carried out to investigate the effect of anemia, caused by dietary iron-deficiency or low-protein, on the pregnant rat and fetus. Three groups of pregnant Sprgue-Dawley rats were respectively fed the control, iron-deficient or low-protein diet. After three weeks of ad lib feeding, all rats were sacrificed, the hematocrit value of blood, the iron content of maternal tissue and fetus, and the nucleic acid of fetal brain were analysed. The results are as follows:
1.There is no difference in the food consumption among three groups. But the low-protein group's body weight gain is lowest (P＜0.05) while other two groups are similar.
2.The weight or product of conception is significantly lower (P＜0.05) in iron- deficient and low-protein groups compared with the control group. The litter size also decrease in iron deficient group. But the average weight of a single fetus is unaffected.
3.The hematocrit value of pregnant rats is significantly lower only in iron-deficient group. However, the fetal hematocrit value is significantly lower not only in iron-deficient group (P＜0.01) but also in low-protein group(P＜0.05).
4.Total iron content of maternal organs (liver and spleen) and fetus are significantly lower in iron-deficient group only (P＜0.01).
5.It shows no difference in fetal brain weight and nucleic acid concentration among three groups.

並列摘要

Anemia is the most prevalent form of malnutrition and it occurs very often in the pregnancy and infancy especially. This study is carried out to investigate the effect of anemia, caused by dietary iron-deficiency or low-protein, on the pregnant rat and fetus. Three groups of pregnant Sprgue-Dawley rats were respectively fed the control, iron-deficient or low-protein diet. After three weeks of ad lib feeding, all rats were sacrificed, the hematocrit value of blood, the iron content of maternal tissue and fetus, and the nucleic acid of fetal brain were analysed. The results are as follows:
1.There is no difference in the food consumption among three groups. But the low-protein group's body weight gain is lowest (P＜0.05) while other two groups are similar.
2.The weight or product of conception is significantly lower (P＜0.05) in iron- deficient and low-protein groups compared with the control group. The litter size also decrease in iron deficient group. But the average weight of a single fetus is unaffected.
3.The hematocrit value of pregnant rats is significantly lower only in iron-deficient group. However, the fetal hematocrit value is significantly lower not only in iron-deficient group (P＜0.01) but also in low-protein group(P＜0.05).
4.Total iron content of maternal organs (liver and spleen) and fetus are significantly lower in iron-deficient group only (P＜0.01).
5.It shows no difference in fetal brain weight and nucleic acid concentration among three groups.

並列關鍵字

iron deficiency ； low protein diet ； pregnancy ； fetal growth ； anemia