Effects of a Very-Low-Calorie Diet and Aerobic Exercise on the Metabolism of Skeletal Muscle

極低熱量飲食與有氧運動對骨骼肌代謝之影響

湯馥君(Fu-Chun Tang) ； 龔憶琳(I-Lin Kung) ； 謝伸裕(Shen-Yu Hsieh) ； 許惠恒(Wayne Huey-Herng Sheu) ； 張錦標(Jin-Biou Chang)

《中華民國營養學會雜誌》 20卷3期 (1995/07) Pp. 239-248

https://doi.org/10.6691/JCNS.199507_20(3).0004

摘要

本研究目的在於探討極低熱量飲食與有氧運動對骨骼肌恆定狀況之影響。受試者為18位非肥胖、健康年青男子，均接受為期7日之極低熱量飲食（平均每日約810大卡），並根據體重與年齡而配對分成二組：不運動組及運動組（每日30分鐘之中低弦度有氧運動，最大心跳率60-80%）。實驗結果發現組間之每日體重、體脂肪百分比及空腹血糖值均無顯著差異性。實驗後兩組體重均顯著下降，但體脂肪百分比之下降僅運動組達到顯著差異。實驗最後一日，運動組之尿中3-甲基組氨酸含量顯著升高，且其尿氮含量顯著高於同日之不運動組。除此之外，每日之組間尿中 3-甲基組氨酸及尿氮含量均無顯著差異。當整合6日（第2日至第7日）的氮平衡值後(n=45)，兩組均呈負氮平衡，且運動組較不運動組為嚴重。不運動組之3-甲基組氨酸及尿氮含量也有增加之趨勢。但兩組尿中羥基脯氨酸及肌氨酸酥含量則無顯著差異。本研究證實採用極低熱量飲食與有氧運動之減量方法會增加3-甲基組氨酸及尿氮之排泄，顯示長期採用此法來減重，有可能會加速體蛋白之分解，而影響到骨骼肌之恆定狀況。

關鍵字

極低熱量飲食 ； 運動 ； 蛋白質分解

並列摘要

The purpose of this study was to investigate whether the effects of a very-low-calorie diet (VLCD) and aerobic exercise affect the homeostasis of the skeletal muscle. Eighteen non-obese, young males received 7 days of a VLCD providing ~ 810 kcal/day. Groups, assigned basing on the match of body weight and age, were diet only (DN) and diet plus daily 30 mm aerobic exercise (low/moderate, HRmax 60-80%) (DE). Changes in body weight, percent body fat, and fasting blood glucose were not different between the groups, on a daily basis. In either group, the body weight was decreased after the experiment (p＜.05).But, only the percent body fat of the DE group was significantly decreased after the experiment (p＜.05). The 3-methylhistidine (3MH) excretion of the DE group was elevated after the treatments of diet and exercise (p＜.05). On day 7, the urea nitrogen excretion of the DE group was significantly higher than that of the DN group (p＜.05). Other than that, there were no significant differences, on a daily basis, in the 3MH and urea nitrogen excretions between the two groups. The pooled data (n=54) of nitrogen balance for both groups were negative. The pooled data of urea nitrogen in the DE group was significantly higher than that in the DN group. Both the 3MH and urea nitrogen excretions of the DN group tended to be increased. The hydroxyproline (Hyp) and creatinine excretions were no significantly different between the two groups. The effects of a VLCD and aerobic exercise resulted in a negative nitrogen balance, and increased 3MH and urea nitrogen excretions, which support the previous report of increased muscle protein degradation during energy deficit.

並列關鍵字

VLCD ； exercise ； protein degradation