血清瘦體素濃度對減重成效的影響

Effects of Serum Leptin on the Effectiveness of Weight Loss

黃美智(Mei-Chich Huang) ； 謝明哲(Ming-Jer Shieh) ； 廖芳瑄(Fang-Hsuean Liao) ； 陳金發(Chin-Fa Chen) ； 劉惠菁(Hui-Ching Liu) ； 簡怡雯(Yi-Wen Chien)

《中華民國營養學會雜誌》 29卷3期 (2004/09) Pp. 168-175

https://doi.org/10.6691/JCNS.200409_29(3).0005

摘要

本研究的目的主要是探討血清瘦體素濃度與減重成效的相關性。實驗期為八週，給予肥胖者每天1200大卡（醣類：55%，脂肪：20%，蛋白質：25%）。在實驗結束後3個月，追蹤其體組成和血液生化值的改變。受試者（n=18；女性14位、男性4位）平均年齡39±1.7歲、體重73.0±2.4公斤；體重、脂肪重、肌肉重、身體質量指數、身體總水重、蛋白質重、休息時的代謝速率、體脂肪百分比均顯著的降低；瘦體素和胰島素濃度均顯著的降低。在八週後，體重平均減輕3.9公斤；體重、脂肪重、肌肉重、身體質量指數、身體總水重、蛋白質重、休息時的代謝速率、體脂肪百分比以及腰臀比均顯著的降低。在實驗結束後三個月，體重平均增加1.1公斤；體重、脂肪重、身體質量批數以及腰臀比均顯著的增加。在血漿瘦體素濃度與體重變化的相關性方面，四週和八週後體重變化均與基礎血清瘦體素濃度和基礎血清瘦體素濃度/身體質量指數呈顯著的正相關。因此，在減重期間，基礎血漿瘦體素濃度越高，可能性減輕較多的體重，且瘦體素濃度的變化可以預測其後的減重成效。

關鍵字

肥胖 ； 瘦體素 ； 體重減輕 ； 瘦體素濃度改變 ； 低熱量飲食

並列摘要

The purpose of this study was to assess the correlation of serum leptin concentration with the effectiveness of weight loss. Eighteen subjects (four males and fourteen females) were provided with 1200 kcal/day (CHO, 55%; fat, 20%; and protein, 25%) commercial packages were used to replace two meals for 8 weeks; and patients were followed-up for 3 months. Subjects were aged 39 ± 1.7 years, with an initial body weight of 73.0 ± 2.4 kg, body mass index (BMI) of 28.2 ± 0.8 kg/m^2, and body fat mass percentage of 33.1% ± 1.5%. After 4 weeks in the weight loss program, the average weight loss was 2.6 kg. Body weight, fat mass, muscle mass, BMI, total body water, protein weight, basal metabolic rate (BMR), and body fat percentage all significantly decreased (p＜O.O5). After 8 weeks of the weight loss program, the average weight loss was 3.9 kg. Body weight, fat mass, muscle mass, BMI, total body water, protein weight, RMR, body fat percentage, and waist-hip ratio all significantly decreased (p＜0.05). At the 3-month follow-up, the average weight loss regained was　1.1 kg, and the weight, fat mass, BMI, and waist-hip ratio had significantly increased (p＜0.05). The 4- and 8-week weight changes were significantly positively correlated with the baseline leptin concentration and baseline leptin/BMI ratio. Therefore, during the weight loss program, subjects who lost more weight had higher baseline leptin concentrations, and leptin concentration changes predicted subsequent weight loss.

並列關鍵字

obesity ； leptin ； weight loss ； leptin concentration change ； low-energy diet