The Influence of Dopamine on the Cardiovascular Effects of Shock Plasma

Dopamine對休克血漿心臟血管作用之影響

盧信祥(Hsin-Hsiang Lu) ； 謝介昌(Chieh-Chang Hsieh)

《Journal of Medical Sciences》 1卷4期 (1976/12) Pp. 341-349

摘要

本實驗利用離體兎心乳頭肌與上腸系膜動脈探討dopamine對休克動物血漿之心肌抑制與血管收縮作用之影響。實驗結果顯示，與對照血漿比較，休克血漿具有極明顯之降低心肌收縮與增強血管張力之作用。休克血漿所含之鉀離子濃度較對照血漿高，鈣離子濃度較對照血漿低。此等離子濃度調整後，休克血漿之心肌抑制與血管收縮作用仍然存在。乳頭肌與血管標本經dopamine處理後，休克血漿之心肌抑制與血管收縮作用不復明顯。動物如先經dopamine滴注處理再令出血休克，其休克血漿無心肌抑制與血管收縮作用。若休克血漿之作用確來自其所含之休克物質，則dopamine不僅具有對抗休克物質之作用，且可防止該等物質之產生。

並列摘要

The infIuence of dopamine upon the cardiovascular effects of the shock plasma was studied on the isolated rabbit papillary muscle and superior mesenteric artery. Shock plasma was obtained from rabbits in the terminaI state of hemorrhagic shock. It was found that shock plasma suppressed the contractility of the papillary muscle and increased the tension of the arterial strips. Both the myocardial depressant and the vasoconstricting effects of the shock plasma could be reduced or abolished completely by dopamine. Shock plasma obtained from rabbits pretreated with dopamine had neither myocardiaI depressant nor vasoconstricting effect. Results of the study suggest that dopamine counteracts the action and prevents the production of the cardiovascular acting substance produced by hemorrhagic shock.