Antidiuretic Response to Small Degrees of Hemorrhage

小量出血時的抗利尿反應

黃萬出(W. C. Huang) ； 李榕生(R. S. Lee) ； 楊志剛(T. K. Young)

《Journal of Medical Sciences》 1卷4期 (1976/12) Pp. 351-357

摘要

正常大白鼠於Inactin麻醉下放血，探討在小量失血時抗利尿反應的成因。經重複而遞增地進行小量放血，以恰能導致有意義的抗利尿作用之最小失血量視為失血閾值，並測出此失血閾值為估計全血量的11%。雖然在小量失血時伴有輕微的平均動脈血壓下降，但由靜脈注射Phentolamine使之產生與閾值失血時相同程度的血壓下降，並不會改變尿流量。此結果顯示小量失血時的抗利尿反應並非由於血壓下降而是源於循環血量減少促使抗利尿素分泌所致。

並列摘要

Antidiuresis in response to small amounts of bleeding was studies in rats under Incatin anesthesia. With a progressive increase in the amount of bleeding, the minimum blood loss which produced antidiuretic effect was found to be 11% of the estimated total blood volume. Minor reduction of mean arterial blood pressure was also observed with this threshold amount of blood loss. However, no significant alteration in urine flow was obtained at a comparable hypotension induced by intravenous injection of phentolamine. These results suggest that antidiuresis occurring in small degree of hemorrhage was not due to a reduction of arterial blood pressure but was exerted by vasopressin release.