維生素丙治療C3H小鼠乳癌的效應

Antineoplstic Effect of High Dosage Vitamin C on C M Mouse Mammary Carcinoma

陳光耀(K. Y. Chen) ； 鍾正華(C. H. Chung)

《Journal of Medical Sciences》 3卷2期 (1979/07) Pp. 879-885

摘要

本實驗以自然發生的乳癌，移植至同種C3H小鼠右後腿皮下，以觀察高劑量的維生素丙的餵食，是否有抗癌作用。以4 gm/公斤體重的維生素丙溶液在乳癌接種之前、乳癌接種當天、和乳癌生長至10 mm時，連續12天上下午各以胃管法餵食一次，並與對照組（沒有餵食維生素丙）觀察所得比較。結果發現在乳癌接種之前餵食維生素丙，有輕微的乳癌生長抑制作用，和輕微的小鼠生存期延長作用；如在乳癌接種當天開始餵食維生素丙，對乳癌生長速度的抑制作用極微；俟乳癌生長至10 mm直徑才開始給以上述劑量的維生素丙治療，則對乳癌生長的抑制和小鼠生存期的延長，均無作用。在缺乏進一步動物腫瘤試驗支持維生素丙的抗癌效用之前，維生素丙對人類腫瘤的抗癌作用，應進行更嚴格的前瞻式臨床試驗，以評估維生素丙的抗癌效果。

並列摘要

Using spontaneously-occurred, transplantable memmary carcinoma implanted into the subcutaneous region of the right hind leg of syngeneic inbred C3H mice, this experiment attempted to demonstrate the antineoplastic effect of high dosage vitamin C by gastric administration. A dose of 4gm/kg body weight of vitamin C solution was given twice per day for 12 consecutive days for the 3 groups of mice; (1) immediately before tumor implantation; (2) the day of tumor implantation, and (3) when the tumors were 10 mm in diameter. The control group of mice were implanted with the same carcinoma, but did not receive vitamin C treatment. The result indicated that vitamin C suppressed tumor growth slightly, and prolonged the host’s life minimally if vitamin C was administered before tumor implantation. The therapeutic effect was negligible, when vitamin C was given on the day of tumor implantation. There was practically no antineoplastic effect if vitamin C was administered when the tumor reached 10 mm in diameter. If there is no further stron evidence to support the antineoplastic effect of vitamin C from animal tumor models, it may be necessary to conduct a well-planned prospective study in human cancer systems before vitamin C can be accepted as an effective antineoplastic agent clinically.