Schönlein-Henoch Purpura: Retrospective Study of 31 Cases

自1981年至1985年，三軍總醫院共有夏林－漢諾氏紫斑症病例31例。他們都有紫斑樣皮膚病灶。發現有血尿或蛋白尿的病例有17例，其中3例接受腎臟活體組織檢查顯示2例為局部增生性腎絲球腎炎，1例為新月性（crescentic）腎絲球腎炎，免疫螢光檢查都呈現明顯的IgA沉積。有關節痛或關節炎的有19例，主要是分佈於膝關節及踝關節。25例有胃腸道的症狀，其中18例有胃腸道出血。8例在胃鏡檢查中發現胃及十二指腸黏膜有血斑點，3例在大腸鏡檢查呈現直腸、大腸或迴腸有類似的出血斑點。在成人組的平均血清IgA濃度有增高的現象。有10例患者因為嚴重的胃腸道症狀而接受prednisolone每日15至60mg之治療。有7例因為紫斑樣皮膚病灶嚴重且一再復發而接受dapsone每日50至100mg的治療。在所有31例患者中，沒有人死亡，有一例患者發生腎病徵候群（nephrotic syndrome），另有一例因尿毒症而接受血液透析治療。

關鍵字

夏林－漢諾氏紫斑症

並列摘要

Between 1981 and 1985, there were 31 patients with Schönlein-Henoch purpura collected in this study. They all had skin lesions. Hematuria and/or proteinuria were found in 17 cases; 3 of them received renal biopsy, in which 2 showed focal proliferative glomerulonephritis and 1 showed crescentic glomerulonephritis under light microscopy, and all 3 showed predominant IgA deposits under immunofluorescent microscopy. Arthralgia and/or arthritis occurred in 19 cases and mostly involved knees and ankles. Twenty-five patients had gastrointestinal symptoms and 18 had gastrointestinal bleeding. Gastroscopic examination in 8 cases revealed multiple hemorrhagic spots or petechiae on the mucosa of stomach and duodenum, and colonofibroscopic examination in 3 cases disclosed similar pictures on the rectum, colon or ileum. The mean serum IgA was elevated only in the adult group. Ten cases were treated with prednisolone, 15 to 60 mg daily, for gastrointestinal distress. Dapsone, 50 to 100 mg daily, was given to 7 cases who had severe and recurrent purpuric rash. Nephrotic syndrome developed in one case and uremia in another patient who eventually was on hemodialysis.

並列關鍵字

Schönlein-Henoch purpura

國際替代計量

Schönlein-Henoch Purpura: Retrospective Study of 31 Cases

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