高壓氧治療與慢性骨髓炎

Hyperbaric Oxygen and Chronic Osteomyelitis

熊震宇(Jen-Yu Schoung) ； 謝學法(Richard Hsieh) ； 魏華儀(Hwa-Ye Wei)

《Journal of Medical Sciences》 7卷6期 (1987/05) Pp. 309-316

摘要

Between 1976 and 1984, 112 patients with chronic osteomyelitis have been treated with hyperbaric oxygen as an adjunct to surgical therapy and antibiotics at Kee-Lung Naval Hospital. 82 patients included in this study, the patient must: (1) have had the infection for at least 3 months, (2) have undergone at least one surgical procedure, (3) have been treated with parenteral antibiotics, and (4) have a minimum follow-up of two years following our combined treatment regimen. Of these 82 patients, 74 patients (90.2%) remain free of clinical sign of osteomyelitis after an average of 49.6 months follow-up. The recurrence seems to be related to chronicity of the infection and times of previous surgical procedures, (p＜0.05). All of the three cases of refracture following treatment got recurrence, we believe that rigid fixation and refrature prevention were the most important principle of treatment. In spite of these encouraging results, we are careful not to term these cases cured of their chronic osteomyelitis. A much longer follow-up is essential before a true cure rate can be determined. We believe that hyperbaric oxygen therapy is indicated as an adjunct to improve results of surgical-antibiotic treatment plans in patients with chronic osteomyelitis in which other treatment modalities have failed.

關鍵字

慢性骨髓炎 ； 高壓氧

並列摘要

Between 1976 and 1984, 112 patients with chronic osteomyelitis have been treated with hyperbaric oxygen as an adjunct to surgical therapy and antibiotics at Kee-Lung Naval Hospital. 82 patients included in this study, the patient must: (1) have had the infection for at least 3 months, (2) have undergone at least one surgical procedure, (3) have been treated with parenteral antibiotics, and (4) have a minimum follow-up of two years following our combined treatment regimen. Of these 82 patients, 74 patients (90.2%) remain free of clinical sign of osteomyelitis after an average of 49.6 months follow-up. The recurrence seems to be related to chronicity of the infection and times of previous surgical procedures, (p＜0.05). All of the three cases of refracture following treatment got recurrence, we believe that rigid fixation and refrature prevention were the most important principle of treatment. In spite of these encouraging results, we are careful not to term these cases cured of their chronic osteomyelitis. A much longer follow-up is essential before a true cure rate can be determined. We believe that hyperbaric oxygen therapy is indicated as an adjunct to improve results of surgical-antibiotic treatment plans in patients with chronic osteomyelitis in which other treatment modalities have failed.

並列關鍵字

Chronic osteomyelitis ； Hyperbaric oxygen