An Immunohistochemical and Ultrastructural Study of Granular Cell Tumor of the Breast-A Case Report and Review of Relative Literature

一乳房之顆粒狀細胞瘤之免疫組織化學染色及電子顯微鏡觀察－一病例報告及文獻回顧

張俊梁(Junn-Liang Chang) ； 陳安(Ann chen) ； 曾暉華(Huei-Hua Tzeng) ； 杜炎昌(Yen-Chang Tu.)

《Journal of Medical Sciences》 10卷6期 (1990/12) Pp. 391-396

摘要

乳房之顆粒狀細胞瘤為少見之疾病，其於肉眼外觀及顯微鏡觀察下極易診斷為乳房之惡性瘤，且腫瘤經初步切除，於冰凍切片檢查時常被誤診為惡性瘤。本病例為－61歲女性患乳房之顆粒狀細胞瘤，腫瘤經初步切除且經免疫組織化學染色法對S－100 protein呈陽性反應及電子顯微鏡觀賞顯示於腫瘤細胞質存在有多量之lysosmes及散在之angulate bodies而確定診斷。由結果顯示，乳房之顆粒狀細胞瘤可能源自神經脊演化成之周邊神經之相關性細胞。本文特提出討論及文獻之回顧。

關鍵字

顆粒狀細胞瘤 ； 惡性顆粒狀細胞瘤 ； 免疫組織化學染色法 ； 電子顯微鏡觀察

並列摘要

Granular cell tumor (GCT) of the breast is an uncommon benign lesion that is grossly and microscopically similar to mammary invasive carcinoma. Thus, it is highly possilbe to misdiagnose this benigh lesion as a malignancy on rapid frozen sections. Herein, we report a case of a 61-year-old woman with GCT of the breast. Immunohistochemically, tumor cells demonstrated positive immunoreactivity for S-100 protein, but showed negative immunostaining for neuron specific enolase (NSE), carcinoembryonic antigen (CEA) and estrogenic receptor (ER). Ultrastructural observations revealed numerous lysosomes bodies and scattered angulate bodies in the cytoplasm of these tumor cells. The basal lamina was also found occasionally surrounding some of these tumor cells. These findings suggest that the GCT might likely have arisen from neural crest-derived peripheral nerve-related cells. The literatures would be reviewed and discussed.

並列關鍵字

Granualr cell tumor (GCT) ； Malignant granualr cell tumor ； Immunohistochemical stains ； Ultrastructural observations