A total of 46 patients with a diagnosis of UTI were treated orally with cefixime 400 mg once daily for 5-7 consecutive days. In 20 cases of uncomplicated UTI, both clinical and bacteriological response rates were 100%, while the rates in 26 cases of complicated UTI were 73.1% and 79.3% respectively. These were considered to be excellent results, especially in uncomplicated cases. Adverse reactions of the drug were rare and mild. Cefixime is well tolerated and very effective in the treatment of acute urinary tract infections.