We have treated 665 patients with palmar hyperhidrosis under endoscopy technique at the Tri-Service General Hospital from May. 1991 to Sep. 1992. In 1330 sides of operation, we have done 1304 sides successfully. Patients have mild to severe degree of chest pain variablely after operation. For relief of the uncomfortable chest pain, we chosed 22 patients and compared their visual analogue scale (V.A.S.) after randomly unilateral interpleural administration of 0.5% Bupivacaine 20 ml with double blind method. There are 4 patients with chest pain in not treated side V.A.S. (0-100 mm) less than 20 mm. It revealed no significant difference of both chest pain after one side interpleural administration of Bupivacaine solution. There are 18 patients with chest pain in not treated side V.A.S. greater than 21 mm. It showed significant pain relief over the interpleural administration side of chest. We considered the interpleural analgesia can successfully provide endoscopic sympathectomy patients with good pain control after operation.