- 期刊
- OpenAccess
Ceftizoxime Sodium與Ranitidine HCl於5%葡萄糖靜脈注射輸送中化學安定性之研究
Chemical Stabilities of Ceftizoxime Sodium and Ranitidine Hydrochloride in 5% Dextrose Injection
摘要
本研究以高壓液相層析儀進行探討Ceftizoxime Sodium及Ranitidine HCl於5％葡萄糖靜脈注射輸送液中之化學安定性。本實驗採用三種不同之Ranitidine藥物劑型，進行安定性之研究。以5％葡萄糖靜脈注射輸送液配製含Ceftizoxime 5.0 mg/ml及Ranitidine 0.5 mg/ml之靜脈混合液，分別於25±1℃之條件下儲存，於一定時間，分別取樣2 ml，予以測定pH值及外觀之觀察外，同時以發展之安定性指示分析法，對Ceftizoxime及Ranitidine分別予以定量。實驗結果顯示，不同之Ranitidine藥物劑型，於25±1℃之儲存條件下儲存，獲不同之安定性。
並列摘要
The chemical stability of ceftizoxime sodium and ranitidine HCl in 5% dextrose injection was studied using a HPLC method. Three brands of commercial ranitidine injections were investigated in this study. Ceftizoxime and ranitidine were diluted with 5% dextrose injection to form an admixture with a ceftizoxime concentration, 5.0 mg/ml, and a ranitidine concentration, 0.5 mg/ml. These admixtures were stored at 25°C until sampling. A 2 ml sample taken in a proper interval was visually inspected, tested for pH, and assayed by a stability-indicating high-performance liquid chromatographic method. Triplicate studies were done for eacd storage condition. The chemical stabilities of admixtures varied with three commercial ranitidine injections introduced in 5% dextrose injection at 25°C.