Although migraine is common in the young adults, it rarely constitutes a significant health risk to the patient. Nevertheless, migraine can lead to catastrophic neurologic consequences. Herein, we describe an unusual case of migraine stroke in a 31 year-old unmarried female. She suffered from recurrent attack of common migraine for many years. She had left hemiplegia, hemianopsia and hemichorea after a migraine attack. CT scan and MRI studies revealed multiple low density lesions over the right thalamus, internal capsule, hippocampus, and occipital lobe. MRA disclosed small caliber and decreased blood flow of right posterior cerebral artery. Series examinations including VORL, HIV, C3, C4, ANA, ESR, CXR, EKG, cardioechogram, and CSF studies showed unremarkable. After medical treatment, her neurological deficits improved gradually. She did not had another cerebral ischemic attack in spite of occasional migraine attack. The epidemiology, risk factors, treatment and pathogenesis of migraine stroke are also discussed in the text.