肺癌轉移腦垂體併發尿崩症和全部腦垂體激素分泌不足－病例報告

Diabetes Insipitus and Panhypopituitarism due to Adenocarcinoma of Lung with Pituitary Gland Metastasis

藍國徵(Kuo-Cheng Lan) ； 陶宏洋(Hung-Yang Tao) ； 許惠恆(Wayne Huey-Herng Sheu) ； 李超群(Chau-Chin Lee)

《Journal of Medical Sciences》 17卷6期 (1997/06) Pp. 386-390

摘要

身體某些癌症可以轉移到下視丘腦垂體軸，而引發臨床症狀，其中以男性的肺癌和女性的乳癌最常見。根據統計，癌症轉移到腦垂體的機率比下視丘高，尿崩症是最常出現的症狀，同時也是與腦垂體腺瘤鑑別的重要臨床特徵。因癌症轉移腦垂體，併發全部腦垂體激素分泌功能不足，在臨床上相當罕見。本篇報告—肺腺癌病例，以臨床特徵、放射學影像和內分泌激素分析，證實癌症轉移腦垂體，引發尿崩症和全部腦垂體激素分泌功能不足。

關鍵字

肺癌腦垂體轉移 ； 腦垂體腺瘤 ； 尿崩症 ； 全部腦垂體激素分泌不足

並列摘要

Metastasis to the hypothalamic-pituitary axis is a recognized event in some forms of systemic cancer. Of the solid tumors which metastasize to the pituitary, carcinoma of the lung and breast are the most frequent. In symptomatic cases, diabetes insipidus (DI) is the usual clinical manifestation, especially seen in the terminal stages. The presence of DI is the single most important feature in differentiating a pituitary adenoma from metastasis. Clinical panhypopituitarism caused by cancer with pituitary invasion is very rare. This report concerns a lung cancer patient who had solitary pituitary metastasis with diabetes insipidus and panhypopituitarism, which was documented by clinical manifestation, contrast-enhanced computed tomographic scan and magnetic resonance image, and endocrinologic studies.

並列關鍵字

pituitary metastasis ； pituitary adenoma ； diabetes insipidus ； panhypopituitarism