Compatibility of Ceftizoxime Sodium and Famotidine in 5％ Dextrose Injection

Ceftizoxime sodium及Famotidine於5%葡萄糖靜脈注射輸送液中配伍性之研究

王孟廷(Meng-Ting Wang) ； 李貫棠(Derek K. T. Lee) ； 黃志賢(Chi-Yin Wong) ； 王大鵬(Da-Peng Wang)

《Journal of Medical Sciences》 18卷1期 (1997/08) Pp. 29-33

摘要

本研究以高壓液相層析儀進行探討Ceftizoxime及Famotidine於5％葡萄糖靜脈注射輸送液中配伍性，以5％葡萄糖靜脈注射輸送液配製含Cefitizoxime 5 mg/ml及Famotidine 0.2 mg/ml之靜脈注射混合液，分別於4℃及25℃之不同條件下儲存，於0.25、2、5、10、24、48、96、168及240小時，分別取樣2ml予以測定pH值及外觀之觀察外，同時以發展之HPLC安定性指示分析法對Ceftizoxime及Famotidine分別予以定量。實驗結果顯示，Ceftizoxime及Famotidine於5％葡萄糖靜脈注射輸送液中，於25℃條件下，僅可僅存168小時，然於4℃條件下，至少可儲存240小時。

關鍵字

葡萄糖靜脈注射輸送液 ； 儲存 ； 高壓液相層析儀 ； 配伍性

並列摘要

The compatibility of ceftizoxime sodium and famotidine in 5% dextrose injection stored at two temperature was studied.Ceftizoxime sodium and famotidine were reconstituted or diluted with 5% dextrose injection to form an admixture with a famotidine concentration of 0.2 mg/ml and a ceftizoxime concentration 5 mg/ml. The admixture was stored in 100-ml vented i.v. containers in the dark at 4 and 25℃; three containers were stored at each temperature. A 2-ml sample was taken from each container after 0.25, 2, 5, 10, 24, 48, 96, 168 and 240 hours of storage and visually inspected, tested for pH, and assayed by a stability-indicating high-performance liquid chromatographic method. Triplicate studies were done for each storage condition.No color change or precipitation was observed in any sample at any time during the study. More than 90% of the initial concentrations of both drugs remained for 240 hours at 4℃ but 168 hours at 25℃.Under the conditions of this study, ceftizoxime 5 mg/ml and famotidine 0.2 mg/ml in adimixture in 5% dextrose injection are stable for only 168 hours at 25℃ and for at least 240 hours at 4℃.

並列關鍵字

Ceftizoxime sodium ； famotidine ； dextrose injection ； storage ； HPLC ； compatibility