A 62-year-old female was admitted to our hospital due to dysphagia and fever. The chest CT scan showed thickness of the esophageal wall. The flexible esophagoscopy found a double-barreled esophagus. The blind-end false lumen showed an accumulation of pus-like fluid, but there was no extravasation of contrast medium in the barium esophagography. After admission, the patient was treated conservatively, which included nothing by mouth and supported by parenteral nutrition for three weeks. A repeat flexible esophagoscopy showed the dissected mucosal flap had progressively reattached. On the 36th day after admission, oral fluids intake was well tolerated. She was discharged 2 months after admission in a good healthy status and was swallowing normally with a soft diet. The prognosis for spontaneous intramural perforation of the esophagus is excellent under conservative therapy but close follow-up is necessary.