The Clinical Significance of Assay Serum Collagen IV 7S Collagen in Patients with Hepatitis B-Related Liver Disease

在不同肝病中（乙型肝炎相關）測定血清7S第4型膠原的臨床意義

唐鴻舜(Hung-Shang Tang) ； 胡幼圃(Oliver Yoa-Pu Hu) ； 趙有誠(You-Chen Chao) ； 楊東和(Ton-Ho Young) ； 胡德民(Teh-Min Hu)

《Journal of Medical Sciences》 18卷5期 (1998/04) Pp. 306-315

摘要

Type IV collagen (IV-C) is one of the main component of basement membrane. The purpose of this study was to assess the clinical significance of assay serum IV-7S (7S collagen) in patients with hepatitis B related liver disease. Compared with a prognostic value of the Child-Pugh's score, and the Galactose elimination capacity (GEC) test.Serum collagen IV-75 (7S collagen) was measured in 176 patients with hepatitis B-related liver disease and 20 healthy controls. 7S collagen was determined with a radioimmunoassay kit purchased from Nippon DPC corporation (Tokyo, Japan). Galactose elimination capacity (GEC) was calculated according to Tysgstrup's equation.The serum concentrations of 7S collagen (mean ±SD) were 3.41 ± 0.62 ng/ml in controls, 6.23 ± 3.47 ng/ml in acute hepatitis (AH), 7.1 ± 5.34 ng/ml in chronic hepatitis (CH) and 14.71 ± 8.l9ng/ml in liver cirrhosis (LC). In CH, 7S collagen concentration was slightly increased than that in the control. In LC, 7S collagen concentration was markedly increased than that in the control, AH and CH. 7S Collagen did not correlate with serum ALT levels in AH and CH but there have been relationships between serum ALT levels and 7S collagen concentration in patients with LC. In patients with LC, the serum concentrations of 7S collagen was significantly correlated with the serum levels of albumin and compared with a Child-Pugh score (pcO.01), but Galactose elimination capacity (GEC) values had a more significant relationship compared with the Child-Pugh score (p＜0.001).These data suggested that the serum concentration of 7S collagen could be useful for evaluation of the disease process of hepatitis B-related liver disease but the prognostic value of the GEC was by far superior to the serum concentration of 7S collagen.

關鍵字

第4型膠原 ； 7S膠原 ； 乙型肝炎肝病 ； 半乳醣排除能力 ； Child-Pugh值

並列摘要

Type IV collagen (IV-C) is one of the main component of basement membrane. The purpose of this study was to assess the clinical significance of assay serum IV-7S (7S collagen) in patients with hepatitis B related liver disease. Compared with a prognostic value of the Child-Pugh's score, and the Galactose elimination capacity (GEC) test.Serum collagen IV-75 (7S collagen) was measured in 176 patients with hepatitis B-related liver disease and 20 healthy controls. 7S collagen was determined with a radioimmunoassay kit purchased from Nippon DPC corporation (Tokyo, Japan). Galactose elimination capacity (GEC) was calculated according to Tysgstrup's equation.The serum concentrations of 7S collagen (mean ±SD) were 3.41 ± 0.62 ng/ml in controls, 6.23 ± 3.47 ng/ml in acute hepatitis (AH), 7.1 ± 5.34 ng/ml in chronic hepatitis (CH) and 14.71 ± 8.l9ng/ml in liver cirrhosis (LC). In CH, 7S collagen concentration was slightly increased than that in the control. In LC, 7S collagen concentration was markedly increased than that in the control, AH and CH. 7S Collagen did not correlate with serum ALT levels in AH and CH but there have been relationships between serum ALT levels and 7S collagen concentration in patients with LC. In patients with LC, the serum concentrations of 7S collagen was significantly correlated with the serum levels of albumin and compared with a Child-Pugh score (pcO.01), but Galactose elimination capacity (GEC) values had a more significant relationship compared with the Child-Pugh score (p＜0.001).These data suggested that the serum concentration of 7S collagen could be useful for evaluation of the disease process of hepatitis B-related liver disease but the prognostic value of the GEC was by far superior to the serum concentration of 7S collagen.

並列關鍵字

Child-Pugh score ； Galactose elimination capacity ； Hepatitis B-related liver disease ； Type Ⅳ collagen ； 7S collagen