Combined Hepatocellular-Cholangiocarcinoma: a Case Report and Review of the Literature

肝癌合併膽管癌：一病例報告及文獻回顧

許桓銘(Huan-Mieng Hsu) ； 劉耀基(Yao-Chi Liu) ； 陳登偉(Teng-Wei Chen) ； 趙載光(Dai-Guang Chao)

《Journal of Medical Sciences》 20卷2期 (1999/10) Pp. 84-89

摘要

肝臟原發性惡性腫瘤主要是肝癌及膽管癌，占了95%的比例，同時合併有肝癌及膽管癌的病例小於5%，病人是60歲男性，本身是B型肝炎帶原者30年，腹部電腦斷層顯示肝左葉有直徑約3公分大小腫瘤合併膽管擴張。病人接受肝臟左葉切除手術，病理切片結果有肝癌及膽管癌之惡性細胞分化。回顧相關文獻資料，顯示此類病人預後很差。

關鍵字

肝癌 ； 肝細胞癌 ； 膽管癌

並列摘要

Primary carcinoma of the liver can usually be classified as hepatocellular carcinoma (HCC) or cholangiocellular carcinoma (CCC). Approximately 98¢H of liver cancer is HCC, which originates from the hepatocytes, and approximately 2% is CCC, which originates from the epithelium of the intrahepatic bile duct. The carcinogenic mechanism of HCC correlates with chronic liver disease and with persistent HBV or HCV infection, but CCC has no relation to viral hepatitis. Combined hepatocellular-cholangiocarcinoma is a rare form of primary liver cancer with features of both hepatocellular and biliary epithelial differentiation. The incidence of combined hepatocellular-cholangiocarcinoma among primary liver cancer has been reported to be from 0.3% to 4.7%. We present the case of a 60-year-old Chinese male who was admitted under the impression of R/O HCC or CCC. However, the final pathological diagnosis showed combined hepatocellular-cholangiocarcinoma.

並列關鍵字

liver cancer ； hepatocellular carcinoma ； cholangiocellular carcinoma