Influence of Steroids Therapy on Carboxyterminal Propeptide of Type I Procollagen (PICP) and Carboxyterminal Pyridinoline Cross-Linked Telopeptide of Type I Collagen (ICTP) in Young Male with Nephrotic Syndrome

評估接受類固醇治療之年輕男性腎病症候群對其骨質合成及分解指標之影響

陳金順(Giien-Shuen Chen) ； 朱柏齡(Pau-Ling Chu) ； 林石化(Shin-Hua Lin) ； 郭建偉(Giian- Wei Gao) ； 林裕峰(Yeh-Feng Lin)

《Journal of Medical Sciences》 20卷3期 (1999/12) Pp. 124-132

摘要

Steroid therapy is often administered for patients with nephritic syndrome. It has been reported that long-term steroid therapy could induce osteoporosis. However, there has been no data regarding the effect of short-term steroid therapy on bone turnover. The objective of this study is to investigate the effect of commonly prescribed doses of steroids on bone markers. Ten male patients (mean age: 21 years old, range: 19-28 years old) with a first attack of idiopathic full-blown nephritic syndrome between 1996 and 1997 were enrolled in this study. They all received standard steroid therapy only, and got complete remission. Patients were assessed before inclusion (0: data at entry) and subsequently at 1 month (1: data at 1 month) and 4 month (4: data at 4 month) after steroid therapy. Serum level of albumin (ALB), total cholesterol (T.chol), daily protein loss (DPL), body weight (BW), serum carboxyterminal propeptide of type I procollagen (PICP), pyridinoline cross linked telopeptide domain of type I collagen (ICTP), intact parathyroid hormone (iPHT) and ionized calcium (iCa) all were measured simultaneously. On the other hard, we also congregated nine healthy age matched male as control group (c: data of control group). Data were expressed as mean ± standard error of mean, and were analyzed by one-way ANOVA and Student's t-test. Our results disclosed that a). PICP₀ showed no significant difference compared with PICPс and PICP₄, but had a trend of increment; b). There was no significant difference between ICTP₀ and ICTPс, but ICTP₄ was significantly lower than PICP₀ (5.34±0.39μg/l vs. 7.53±0.69, p＜0.05); c). Both of baseline data of iPTH and iCa compared with 4 month after treatment showed no significant difference. We conclude that there is no obvious change in bone formation and bone resorption in young male idiopathic nephritic syndrome before steroid treatment, and steroid effect was major in local hormone, but not systemic hormone after receiving short-term steroids treatment.

關鍵字

類固醇 ； 骨質代謝指標 ； 腎病症候群 ； 年輕男性

並列摘要

Steroid therapy is often administered for patients with nephritic syndrome. It has been reported that long-term steroid therapy could induce osteoporosis. However, there has been no data regarding the effect of short-term steroid therapy on bone turnover. The objective of this study is to investigate the effect of commonly prescribed doses of steroids on bone markers. Ten male patients (mean age: 21 years old, range: 19-28 years old) with a first attack of idiopathic full-blown nephritic syndrome between 1996 and 1997 were enrolled in this study. They all received standard steroid therapy only, and got complete remission. Patients were assessed before inclusion (0: data at entry) and subsequently at 1 month (1: data at 1 month) and 4 month (4: data at 4 month) after steroid therapy. Serum level of albumin (ALB), total cholesterol (T.chol), daily protein loss (DPL), body weight (BW), serum carboxyterminal propeptide of type I procollagen (PICP), pyridinoline cross linked telopeptide domain of type I collagen (ICTP), intact parathyroid hormone (iPHT) and ionized calcium (iCa) all were measured simultaneously. On the other hard, we also congregated nine healthy age matched male as control group (c: data of control group). Data were expressed as mean ± standard error of mean, and were analyzed by one-way ANOVA and Student's t-test. Our results disclosed that a). PICP₀ showed no significant difference compared with PICPс and PICP₄, but had a trend of increment; b). There was no significant difference between ICTP₀ and ICTPс, but ICTP₄ was significantly lower than PICP₀ (5.34±0.39μg/l vs. 7.53±0.69, p＜0.05); c). Both of baseline data of iPTH and iCa compared with 4 month after treatment showed no significant difference. We conclude that there is no obvious change in bone formation and bone resorption in young male idiopathic nephritic syndrome before steroid treatment, and steroid effect was major in local hormone, but not systemic hormone after receiving short-term steroids treatment.

並列關鍵字

steroid ； PICP ； ICTP ； nephrotic syndrome ； young male