- 期刊
- OpenAccess
Successful Treatment of Metastatic Gastrointestinal Stromal Tumors Using Tyrosine Kinase Inhibitor STI571
並列摘要
Gastrointestinal stromal tumors (GISTs) are a group of mesenchymal neoplasms that arise from the connective tissue cells of the gastrointestinal tract. Malignant GISTs are resistant to chemotherapy and radiation therapy. Complete surgical resection is the best way to cure this disease. However, unresectable conditions, multiple metastases, and postoperative recurrences usually happen in patients with malignant GISTs and the prognosis is disappointing. Recent studies about the proto-oncogene c-kit revealed a ray of hope for the treatment of patients with GISTs. KIT (CD117, a growth factor receptor with tyrosine kinase activity) is the product of the c-kit gene, which is detectable in most GISTs. Mutations of the c-kit gene play an important role of the pathogenesis of the tumors. To block the activity of tyrosine kinase using STI571 (signal transduction inhibitor, imatinib mesylate) was proven effective in treating patients with metastatic or recurrent GISTs. We present a case of metastatic gastric GIST which recurred after a debulky operation. Remission of the recurrent lesions was proven after using STI571.
延伸閱讀
- 游鎧璘（2018）。Care Needs and the Related Factors in Gastrointestinal Stromal Tumor Patients Undergoing Oral Targeted Therapy〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU201803142
- 彭錦池、林作彥、廖浩欽、金霍歌（2008）。Gastrointestinal Stromal Tumors: A Case Report and Literature Review。中華民國急救加護醫學會雜誌，19(3)，113-118。https://doi.org/10.30018/JECCM.200809.0003
- Koumarianou, A., Economopoulou, P., Katsaounis, P., Laschos, K., Dadioti, P. A., Martikos, G., Rogdakis, A., Tzanakis, N., & Boukovinas, I. (2015). Gastrointestinal Stromal Tumors (GIST): A Prospective Analysis and an Update on Biomarkers and Current Treatment Concepts. Biomarkers in Cancer, 2015(S1), 1-7. https://doi.org/10.4137/BIC.S25045
- Liao, W. S., Wang, T. E., Huang, M. J., Zeng, C. Y., & lin, S. C. (2004). The Clinical Significance of CD117(c-kit) in Gastrointestinal Stromal Tumors. 臺灣消化醫學雜誌, 21(2), 115-122. https://doi.org/10.6557/GJT.200406_21(2).0001
- Huang, C. C., Lien, H. H., Huang, C. S., & Sung, Y. C. (2004). Surgical Resection Combined with Systemic Imatinib Therapy for the Treatment of Advanced Gastrointestinal Stromal Tumor. Formosan Journal of Surgery, 37(5), 218-224. https://doi.org/10.29833/FJS.200410.0004