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In the absence of early diagnosis and proper management, a nasal septal abscess, an uncommon entity, may lead to lethal complications. It is most frequently seen in cases of traumatic septal hematoma with subsequent infection but also occurs in cases of furunculosis of the nasal vestibule, sinusitis, influenza, and dental infection. To our knowledge, this is the first case report of a nasal septal abscess developing spontaneously in an immunocompromised and coagulopathic patient. We report this case to reinforce the need for scrupulous evaluation in immunocompromised and coagulopathic patients presenting with nasal obstruction without a history of trauma.

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