Clinical Efficacy of Nutritional Food Supplement in Non-motor Symptoms of Parkinson's Disease

Accumulating evidence supports the notion that oxidative stress and neuroinflammation are involved in the pathogenesis of Parkinson's disease (PD). Meanwhile, imbalanced nutritional status and undernutrition increase the morbidity of Parkinsonian patients. EASE123 (BioNatural Labs, CA) is a nutritional food supplement that contains a variety of natural plants with well-known antioxidant effects. We designed an open-label clinical trial to determine if administration of EASE123 as an auxiliary therapy could alleviate clinical symptoms in patients with PD. Ten patients, 5 male and 5 female, were recruited for this study. Patients presenting with typical Parkinsonian features received pretest imaging including brain MRI scans and cerebral (superscript 99m)Tc-TRODAT-1 SPECT. Then, they were evaluated using UPDRS at pretreatment, during the treatment of EASE123 for 6 weeks at 2-week intervals, and at 2 weeks post-withdrawal. Significant reduction in total scores and subscores, parts I and IV, of UPDRS during the treatment period were noted, but no marked variations for parts II and III of UPDRS were found. Taken together, the results demonstrate that the addition of nutritional food supplement might alleviate PD symptoms through the improvement of non-motor symptoms.

並列關鍵字

Parkinson's disease ； non-motor symptoms ； nutritional food supplement

國際替代計量

全文下載

主題瀏覽