Cutaneous Adverse Drug Reactions in a Tertiary Hospital in Taipei, Taiwan, in 2018

Yi-Hsien Chen ； Tzu-Ling Hung ； Hsiang-Cheng Chen ； Jui-Hu Shih ； Yu-Ju Chiao ； Li-Ching Lin ； Chih-Tsung Hung

《Journal of Medical Sciences》 41卷4期 (2021/08) Pp. 161-166+ap1-5

https://doi.org/10.4103/jmedsci.jmedsci_172_19

摘要

Cutaneous adverse drug reactions (CADRs) are the common adverse reactions ranging from mild self-limiting skin rash to the life-threatening severe cutaneous adverse reactions. Aims: The aim of the study was to describe the demographic characteristics of patients, different clinical patterns, and implicated drugs. Methods: This was a retrospective study by analyzing the database established for all ADRs reported from January 1, 2018, to December 31, 2018, in a tertiary care teaching hospital in Taipei, Taiwan. Results: A total of 126 cases of CADRs were reported in 2018. The mean age of patients was 59.06 ± 21.63 years, with a peaking at 60-79-year-old (31.7%) and followed by 40-59-year-old (25.4%). The male-to-female ratio was 1.03:1. The most common skin reaction pattern was maculopapular eruptions (59.5%), followed by angioedema (11.9%), phlebitis (6.3%), and urticaria (6.3%). Most of the CADRs were reported with antibacterials (66.7%), followed by anti-inflammatory products (11.9%), contrast media (4.8%), and antithrombotic agents (3.2%). Conclusions: We listed the patient characteristics, each pattern of CADRs, and their associated drugs. Such information could help health-care professionals to assess CADRs and evaluate suspected drugs timely and accurately.

關鍵字

Angioedema ； cutaneous adverse drug reactions ； maculopapular eruptions ； urticaria