- 期刊
- OpenAccess
Histopathological Evaluation of Estrogen Receptors, Progesterone Receptors, and Human Epidermal Growth Factor Receptor-2/Neu Expressions in Breast Carcinoma and their Correlations with Other Prognostic Factors: A Hospital-based Study
摘要
Background: Breast carcinoma is a leading cause of death among women. Factors such as estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (HER-2/neu) have important prognostic and predictive value. Aim: The aim of the study is to demonstrate ER, PR, and HER-2/neu expression in breast cancer specimens and to correlate these expressions with other prognostic factors such as tumor size, type, grade, and lymph node status. Methods: This prospective study included 70 cases of female breast carcinoma. Histopathological evaluation of all cases done and tumor size, site, presence, or absence of lymph node was recorded. Typing of tumor, grade, and lymph node status were determined. Immunohistochemical staining for ER, PR, and HER-2/neu of breast lesions was done, and the data were analyzed to find out any correlation of expression of ER, PR, HER-2/neu with the above prognostic factors. Results: The majority of patients were in 41-50 years (44.29%). Most of tumors were 2-5 cm in size and the infiltrating duct carcinoma‑not otherwise specified was the commonest type. ER and PR expression decreases (P = 0.02340 and P = 0.02413 respectively), while HER-2/neu expression increases with increase tumor size (P = 0.02289). ER and PR expression were low while Her-2/neu expression was more in higher tumor grade (P = 0.022472, P = 0.04149 and P = 0.03339 respectively). No significant association was identified between ER, PR, HER-2/neu and number of metastatic lymph node. Conclusion: ER, PR, and HER-2/neu status correlates well with histopathological grading and tumor size. However, no significant association is seen with cancer type and lymph node status.
延伸閱讀
- Kandula, S., Switchenko, J. M., Harari, S., Fasola, C., Mister, D., Yu, D. S., Zelnak, A. B., & Torres, M. A. (2015). Locoregional Recurrence Risk in Breast Cancer Patients with Estrogen Receptor Positive Tumors and Residual Nodal Disease following Neoadjuvant Chemotherapy and Mastectomy without Radiation Therapy. International Journal of Breast Cancer, 2015(), 33-39. https://doi.org/10.1155/2015/147476
- 連景峯、黃澤人、王誌群、林尊湄、陳佳琪、楊顓謙、葉世安、江豐裕（2022）。The Effect of Cortactin Expression on Cervical Nodal Metastasis, Distant Metastasis and Survival-A Cohort Study of 140 Patients with Hypopharyngeal Carcinoma。台灣耳鼻喉頭頸外科雜誌，57(1)，22-29。https://doi.org/10.6286/jtohns.202203_57(1).022
- Philips, N., Tahir, M., Stellatella, J., Stephan, K., Givant, J., Zhou, L., Costa, A., & Taw, M. (2009). Differential Regulation of Growth Factors and Matrix Metalloproteinase-1 by Estrogen, Progesterone, and Tamoxifen in Normal and Cancerous Endometrial Cells. Journal of Cancer Molecules, 4(6), 169-173. https://doi.org/10.29685/JCM.200902.0002
- Lin, H. C., Cheng, C. C., Huang, C. S., Huang, J. H., & Ho, A. S. (2022). Evaluation of Carcinoembryonic Antigen, Vascular Endothelial Growth Factor, Neutrophil Elastase as Serological Biomarkers in Patients with Colorectal Cancer. 中華民國大腸直腸外科醫學會雜誌, 33(2), 51-59. https://doi.org/10.6312/SCRSTW.202206_33(2).11026
- Pentheroudakis, G., Angouridakis, N., Wirtz, R., Nikolaou, A., Kalogeras, K. T., Pavlidis, N., & Fountzilas, G. (2009). Transcriptional Activity of Human Epidermal Growth Factor Receptor Family and Angiogenesis Effectors in Locoregionally Recurrent Head and Neck Squamous Cell Carcinoma and Correlation with Patient Outcome. Journal of Oncology, 2009(), 301-310. https://doi.org/10.1155/2009/854127