多形性膠質母細胞瘤通常爲大腦天幕上之病變,鮮少發生在小腦。自從Carmichael於1928年報告第一例小腦的多形性膠質母細胞瘤之後,文獻上只有少數的病例報告,亞洲地區僅於2004年報告單一病例。因此,我們報告兩例亞裔的小腦多形性膠質母細胞瘤,臨床上病人是以暈眩,步態不穩和明顯的小腦症狀來表現。病人在腫瘤切除手術和術後接受後顱窩之放射治療。在此,我們討論這兩病例的臨床症狀,影像學之表徵,手術的發現,放射治療的策略,以及做文獻的回顧。
Glioblastoma multiforme (GBM) usually arises in the supratentorial region, and rarely occurs in the cerebellum. Cerebellar GBM was first described in 1928 by Carmichael, and only 105 cases have since been reported in the literature. Only one case has ever been reported in Asia. Herein, we report two additional cases of cerebellar GBM occurring in the Asian area. Both patients had a history of dizziness, unsteady gait, and obvious cerebellar signs. Tumor excision along with postoperative posterior fossa irradiation was performed in each case. We discuss the clinical symptoms, radiological features, surgical findings, and radiotherapeutic strategies, and then review the literature.