- 期刊
Inflammation-related Biomarkers in Esophageal Squamous Cell Carcinoma
食道癌中與發炎相關之生物標記
摘要
近年來有許多證據顯示在多數惡性腫瘤中發炎反應在腫瘤發生、惡化及腫瘤抗藥性上據有致命性的角色。發炎反應中所產生之調控物質及發炎細胞影響物質是主要構成腫瘤內微環境重要因子。在腫瘤微環境中「悶燒」式慢性發炎反應能導致腫瘤產生多種促進的影響，如細胞快速增生、存活率增加、血管新生、腫瘤轉移及躲避宿主中免疫細胞攻擊等。與癌症相關發炎反應之分子傳遞機制已被多方研究與了解，其相關研究結果將可被利用於發展新標的分子，且應用於改善癌症的診斷及治療。 在近期食道癌臨床病理腫瘤分期系統並不足以用於預測治療及預後之結果，而此結果之產生相信必定有多種內生性因子所導致。臨床病理證據及發炎相關因子等分生研究上證明慢性發炎和食道癌之發生及惡化進展有明確的相關性，因此充分的了解慢性發炎之因子對於食道癌病人預後之預測、改善治療成效及發展新的治療策略是非常重要的。因此爲了充實發炎反應及食道癌之相關知識，我們在此回顧性論文中總結性的闡明近年來與食道癌相關之發炎因子及其相關機制。
關鍵字
無資料並列摘要
Increasing evidences have expanded the concept that inflammation is a critical component of tumor progression and therapeutic resistance in most types of malignancy. The mediators and cellular effectors of inflammation are important constituents of tumor microenvironment. 'Smoldering' inflammation in the tumor microenvironment induces many tumor-promoting effects, including fostering of cell proliferation and survival, promotion of angiogenesis, tumor invasion/metastasis, and evasion of host immunosurveillance. The molecular pathways of the cancerrelated inflammation are now being unraveled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment. The current clinicopathological staging system for esophageal squamous cell carcinoma (ESCC) is inadequate for predicting the therapeutic response and prognosis. It is believed that multiple intrinsic factors in making the difference of therapeutic responses or outcomes exist. An association of chronic inflammation in the esophagus with tumor initiation and promotion indicates that an understanding on the clinical implications and the pathophysiological regulation of the inflammation-related biomarkers is quite important in prognostic prediction and improvement of therapeutic outcomes, or innovative therapeutic strategy, for ESCC patients. In an attempt to broaden our knowledge, we have, in this review article, also summarized the common mechanisms associated with inflammation-related biomarkers identified in ESCC.
延伸閱讀
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