Thymic carcinoma is a rare tumor in the anterior mediastinum, which is often seen in adults over 40 years old. Typically, it is asymptomatic for a prolonged period of time. An incidental finding of a mass on a chest x-ray film is the most common presentation. Symptomatic patients often complain of chest pain, cough or other upper respiratory symptoms. Pericardial effusion may be present occasionally, but cardiac tamponade is rarely seen. There are only scattered reports of thymic carcinoma presenting with cardiac tamponade. We report a 65-year-old woman with thymic carcinoma who had an episode of near-syncope due to cardiac tamponade. Emergent pericardiocentesis terminated the life-threatening condition. Fine needle biopsy showed a poorly differentiated epidermoid thymic carcinoma. Computed tomography of the chest also proved that tumor extended to the chest wall, pericardium, aorta, pulmonary arteries and superior vena cava.