G-50T Polymorphism of the Cytochrome P450 Epoxygenase CYP2J2 Gene is Not Associated with the Risk of Coronary Artery Disease among Chinese in Taiwan

細胞色素P450環氧化合酶CYP2J2基因上的G-50T多形性與台灣人發生冠狀動脈疾病的危險性沒有相關

許隆安(Lung-An Hsu) ； 柯毓麟(Yu-Lin Ko) ； 張其任(Chi-Jen Chang) ； 王俊力(Chun-Li Wang) ； 賀萬靖(Wan-Jing Ho) ； 柯毓賢(Yu-Shien Ko) ； 許子秀(Tsu-Shiu Hsu) ； 陳偉踐(Wei-Jan Chen) ； 鄭乃仁(Nye-Jan Cheng) ； 郭啟泰(Chi-Tai Kuo)

《Acta Cardiologica Sinica》 22卷3期 (2006/09) Pp. 148-153

摘要

背景　人類細胞色素P450 (CYP) 2J2表現於血管內皮，能將花生四烯酸代謝成環氧二十碳三烯酸。環氧二十碳三烯酸是非常強的血管擴張劑和發炎抑制劑，所以CYP2J2基因上的多形性可能會影響發生冠狀動脈疾病的危險性
方法 利用聚合酶連鎖反應分析總共209 個冠狀動脈疾病病人，（其中114個病人同時有心肌梗塞），和209個與之年齡和性別配對的對照者的CYP2J2基因G-50T 多形性。
結果　冠狀動脈疾病組和對照組兩組之CYP2J2多形性基因型的分佈是相似的，10.5%之冠狀動脈疾病病人，和8.6%之對照者是GT基因型，（勝算比=1.87，95%信賴區間=0.81-4.32，p=0.146）。T對偶基因的比率於冠狀動脈疾病組和對照組兩組之分佈也是相似的，（5.3%相較於4.3%，p=0.506）。帶有G-50T多形性的人與發生心肌梗塞的危險性也沒有有意義的相關。
結論　由我們的資料中，沒有證據顯示CYP2J2基因上的多形性與臺灣人發生冠狀動脈疾病和心肌梗塞的危險性有相關。

關鍵字

多形性 ； 細胞色素P450 ； 冠狀動脈疾病

並列摘要

Background: Human cytochrome P450 (CYP) 2J2 is expressed in the vascular endothelium and metabolizes arachidonic acid to epoxyeicosatrienoic acids (EETs). The EETs are potent vasodilators and inhibitors of inflammation. Thus, the CYP2J2 gene variants may contribute to the risk of coronary artery disease (CAD).
Methods: In total, 209 patients with CAD (114 of them with myocardial infarction [MI]) and 209 age- and sexmatched control subjects were analyzed for the CYP2J2 G-50T polymorphism by polymerase chain reaction.
Results: The distribution of CYP2J2 genotype was similar in the CAD cases and controls; the GT genotype was present in 10.5% of CAD patients, as compared to 8.6% of CAD control subjects (odds ratio=1.87, 95% C.I.=0.81-4.32, p=0.146). The frequency of the T allele was also similar in the CAD cases and controls (5.3% vs. 4.3%, p=0.506). There was also no significant association between G-50T polymorphism carriers and the risk of myocardial infarction.
Conclusion: From our data, there is no evidence of an association between the CYP2J2 G-50T polymorphism and the risk of CAD and MI among Chinese in Taiwan.

並列關鍵字

Polymorphism ； Cytochromes P450 ； Coronary disease