Ebstein's anomaly is frequently associated with atrial septal defect (ASD). This interatrial communication also contributes to systemic desaturation, systemic embolization, pulmonary hypertension, and right-side heart failure. We describe a case of a 25-year-old lady who had central cyanosis and exercise intolerance due to Ebstein's anomaly with ASD. These manifestations markedly improved following closure of the ASD using an Amplatzer septal occluder. In the literature, transcatheter closure device for ASD is safe and effective, however, this has rarely been repotted regarding Ebstein's anomaly.