Takotsubo cardiomyopathy has clinical manifestations mimicking acute coronary syndrome and is characterized by transient left ventricular (LV) dysfunction without significant coronary artery disease. It is not homogeneous; most cases involve the apical area, though some are apex-sparing. We describe a 71-year-old woman with chest pain and dyspnea which occurred a short period after colonoscopy. Urgent coronary angiography and left ventriculograhy were performed, and a variant form of takotsubo cardiomyopathy involving left mid-ventricular wall motion abnormality was diagnosed. The patient was discharged and remained well without chest pain or dyspnea. She was followed up at our outpatient department, and her left ventricular dysfunction recovered completely 3 weeks after discharge.