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Hypertrophyic Cardiomyopathy Associated with Midventricular Obstruction and Apical Aneurysm

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Hypertrophic cardiomyopathy (HCM) with midventricular obstruction (MVO) and left ventricular (LV) apical aneurysm is a rare clinical entity for which only a few sporadic case reports exist in the literature. Herein, we report the case of a 66-year-old man who presented with exertional dyspnea, chest tightness and dizziness for 1 year. Thallium-201 myocardial scintigraphy showed a fixed perfusion defect in the LV apical-inferior wall. Echocardiography showed significant concentric left ventricular hypertrophy, and the left ventricular cavity was shaped like an hourglass, indicating midventricular obstruction. Left ventriculography demonstrated total occlusion at the midventricular level during systole, and an apical aneurysm. Coronary angiography revealed no significant vessel stenosis. The patient was treated with resection of the aneurysm, endoaneurysmorrhaphy and beta blocker therapy. The post-operative course was uneventful. The possible pathophysiology, clinicalmanifestation, diagnosis, and treatment are discussed.

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