Effects of a Novel I(f) Inhibitor; Ivabradine, on the Biochemical, Hemodynamic, and Electrophysiological Parameters in Symptomatic Patients with Mitral Valve Prolapse

Davran Cicek ； H. Olcay Eldem ； Nihat Kalay ； Bulent Ozin ； Haldun Muderrisoglu

《Acta Cardiologica Sinica》 26卷4期 (2010/12) Pp. 253-258

並列摘要

Introduction: We aimed to investigate the effects of ivabradine in symptomatic (sinus tachycardia) patients with mitral valve prolapse. Ivabradine specifically inhibits the If current in the sinoatrial node to lower heart rate without affecting other aspects of cardiac function.
Methods: The study included 48 MVP patients. After 2 weeks of wash-out, echocardiographic, electrocardiographic, 24-hour Holler, and routine blood examinations were conducted. Ivabradine therapy was started at ct dosage of 5 mg twice daily. After 1 mo of treatment, the abovementioned examinations were repeated.
Results: The treatment was completed by 45 patients. No significant differences were observed between the pre-and post-treatment values of the echocardiographic, hemodynamic, and electrophysiological parameters. However, the symptom periods (164±12 vs. 114±9; p=0.003) and the maximum (149±18 vs. 136±16; p=0.001), mean (85±8 vs. 77±8; p=0.002), and minimum heart rates (61±3 vs. 52±5; p=0.001) recorded by Holter monitoring were significantly reduced.
Conclusion: Ivabradine is effective arid safe to relieve palpitation symptoms due to sinus tachycardia in patients with mitral valve prolapse. However, its safety its the longer term will require additional assessment.

並列關鍵字

Antiarrhythmic ； Cardiac pharmacology ； Ion channels ； Mitral valve prolapse ； Tachycardia