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Effect of Preload Reduction by Hemodialysis on Left Ventricular Mechanical Parameters by Three-Dimensional Speckle Tracking Echocardiography

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Background: The effect of acute volume change by hemodialysis on contractile characteristics of the left ventricle (LV) is not well known and has never been evaluated by 3-dimensional speckle tracking echocardiography (3D-STE).Methods: Twenty-three patients on chronic hemodialysis were recruited. 3D-STE was performed immediately before and after hemodialysisin the dialysis room. The strain, displacement, rotation, torsion, and twist of LV were calculated by commercial software for different segments of LV.Results: Hemodialysis produced significant decreases in body weight, systolic and diastolic blood pressure, end-diastolic and end-systolic volumes, but ejection fraction did not change. The regional torsion increased from 2.I ± 1.2 to 2.7 ± 1.3 degree/cm (p =0.012) after dialysis, though the crude global torsion, longitudinal, radial, circumferential, 3D strain, rotation and twist of LV did not change significantly. The regional torsion correlated with the crude global torsion (r = 0.763, P < 0.00I). The change of ejection fraction after hemodialysis was significantly correlated with changes of circumferential strain (r = -0.858, P < 0.00 I), longitudinal strain (r = -0.516, p= 0.012) and LV area (r = -0.883, P < 0.001).Conclusion: Assessment of LV contractile characteristics by 3D-STE is easy and efficient. The regional torsion, which could only be evaluated by 3D-STE is more sensitive to reduction in preload possibly due to deformation non-uniformity of myocardium in uremic patients.

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