- 期刊
Predictive Value of Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Patients with Coronary Slow Flow
並列摘要
Background: Increased microvascular resistance due to chronic inflammation is assumed to be one of the mechanisms associated with coronary slow flow (CSF). Previous studies have shown that the platelet-to-lymphocyte ratio (PLR) and the neutrophil-lymphocyte ratio (NLR) are markers of inflammation for various diseases. In this study we aimed to evaluate the relationship between CSF and PLR-NLR. Methods: Seventy-eight patients with CSF and 50 patients with normal coronary flow were enrolled into this study. The study subjects underwent medical examination and testing, after which their platelet-to-lymphocyte ratios and NLR values were calculated. An independent observer measured the coronary flow rate by Thrombolysis in Myocardial Infarction Frame Count (TFC) method. The platelet-to-lymphocyte ratio and NLR values were compared between the groups and correlation analysis was performed to explore the relationship between mean TFC with PLR and NLR. Results: Platelet-to-lymphocyte ratio and NLR values were significantly higher in patients with CSF (p ＜ 0.001). There was a positive significant correlation between TFC with NLR and PLR (Spearman’s Rho: 0.59, p ＜ 0.001 and Spearman’s Rho: 0.30, p = 0.001, respectively). Multivariate logistic regression analysis revealed that NLR is the one independent predictor for CSF. Conclusions: This study demonstrated an association between CSF and PLR-NLR. Although the exact mechanism could not be explained, our findings support the possible role of inflammation in CSF physiopathology.
延伸閱讀
- Young, C. A., Murray, L. J., Karakaya, E., Thygesen, H. H., Sen, M., & Prestwich, R. J. D. (2014). The Prognostic Role of the Neutrophil-to-Lymphocyte Ratio in Oropharyngeal Carcinoma Treated with Chemoradiotherapy. Clinical Medicine Insights: Oncology, (), 81-86. https://doi.org/10.4137/CMO.S15476
- Tseng, C. H., Chang, Y. J., Chiang, T. H., & Liao, Y. L. (2016). Evaluation of Platelet Volume Indices in Adults with Hyperlipidemia and Correlation with Lipid Ratio. 澄清醫護管理雜誌, 12(4), 10-16. https://www.airitilibrary.com/Article/Detail?DocID=18136702-201610-201610040016-201610040016-10-16
- Wagdy, S., Sobhy, M., & Loutfi, M. (2016). Neutrophil/Lymphocyte Ratio as a Predictor of In-Hospital Major Adverse Cardiac Events, New-Onset Atrial Fibrillation, and No-Reflow Phenomenon in Patients with ST Elevation Myocardial Infarction. Clinical Medicine Insights: Cardiology, 2016(), 19-22. https://doi.org/10.4137/CMC.S35555
- Kiliçkaya, M. M., Tuz, M., YariktaG, M., Yasan, H., AynalJ, G., & Bagci, Ö. (2015). The Importance of the Neutrophil-Lymphocyte Ratio in Patients with Idiopathic Peripheral Facial Palsy. International Journal of Otolaryngology, 2015(), 169-172. https://doi.org/10.1155/2015/981950
- Balci, K. G., Balci, M. M., Arslan, U., Acar, B., Maden, O., Selcuk, H., & Selcuk, M. T. (2016). Increased Platelet-to-Lymphocyte Ratios and Low Relative Lymphocyte Counts Predict Appropriate Shocks in Heart Failure Patients with ICDs. Acta Cardiologica Sinica, 32(5), 542-549. https://doi.org/10.6515/ACS20151012B