Histological Study of Sea Coral as an Implant Material (An Animal Experimental Report)

骨科置取代物“珊瑚”(動物實驗研究報告)

金學志(Hsueh-Chih King M. D.)

《Journal of Orthopaedic Surgery Taiwan》 6卷2期 (1989/06) Pp. 49-57

摘要

目前骨科常選用自體或異體骨移置為處理骨缺陷的原則，然而兩者皆有其利弊，如增加傷口，骨移置本質及其量的問題，故欲利用與人體骨骼組織結構及成分極為相似的自然產物”珊瑚”為骨移置取代物，以避免以上缺點，並仍有骨癒合的結果。
本實驗應用”珊瑚”約(2*1*1 cm) 置入不同五組物的骰骨遠端，經手術后，每隔2週，取得一組標本，做多種不同組織切片，觀察其變化。經12週依次分析不同時段的組織切片，發現並無任何抗斥，發炎等反應，反其表面與寄生體骨骼有極完整的接合，即有新生骨長入”珊瑚”的趨勢。
本實驗結果証實”珊瑚”是一種非具排斥性的自然產物，同時擁有相當適合骨生長的環境。而”珊瑚”本身可視如骨缺陷的填充物。

並列摘要

One centimeter section (2*1*1 cm) of the sea coral was implanted into the distal femur of dogs for 8 to 12 weeks followed by a serial radiographic evaluation and histomorphological investigation. Those sections have been studies by histological method, dissection microscopy, and polarized microscopy. The results had evidenced the good tolerance, the firm tissue adhesive bonding and the similar porous size with around 200-300 micron between the sea coral and bone. No evidence of infection, rejection, or encapsulation was seen. This result demonstrates that it is possible to utilize sea coral as an implant material which allows ingrowth of bone.

並列關鍵字

Sea coral ； Implant ； Porous ingrowth