Elcatonin(合成鰻魚Calctionin之誘導體)對於原發性體質鬆症所引起之腰背痛之臨床效果

The Clinical Effects of Elcatonin to Low Back Pain in Patients with Osteoporosis

陳博光(Po-Quang Chen) ； 劉堂桂(Tang-Kue Lin)

《Journal of Orthopaedic Surgery Taiwan》 7卷1期 (1990/03) Pp. 63-70

摘要

自1982年12月至1987年7月，在台灣大學醫學院附設醫院，骨科門診之骨質疏鬆症且有腰背痛之患者20名，給與Elcatonin 20單位，每星期兩次之肌肉注射，共連續四星期，觀察患者之疼痛改善效果，檢討如下文：
　　臨床症狀之自覺及運動痛，包括起坐、翻身、前後彎曲、步行所引起之疼痛，投與Elcatonin後，於兩星期後有顯著之改善感覺。其改善程度之指標「稍減少」以上者，在受診患者中，全部都表示獲得改善。
　　本實驗中，並無嚴重之副作用，且注射Elcatonin，患者之臨床檢查值，亦無不正常之變化。因此，Elcatonin之給與伴隨骨質疏鬆症之腰背痛，是有效且安全之藥劑治療。

並列摘要

Elcatonin, the calcitonin derived from eel, is biologically very potent, and is stable to light and heat. In this study, 20 patients were selected to observe the analgesic effect of elcatonin. All the patients were diagnosed as primary osteoporosis. The age distribution ranged from 57 to 85 years old. For each patient, 20 units of elcatonin were given intramuscularly twice per week for 4 weeks. Patients were evaluated at outpatient clinic every week. According to Jikei classification of spinal osteoporosis, 5 were grade I, 9 grade II, and 6 grade III; according to singh’s classification of the trabecular pattern of the hip (16 patients), one was grade 1,4 grade 2,7 grade 3,3 grade 4 and 1 grade 5. Eight patients (40%) had associated compression fracture, 4 had spondylosis. The results were evaluated by relief of spontaneous pain, improvement of daily activities, such as sitting, turning, standing and walking ability. At 4 weeks, back pain disappeared completely in 2 patients, markedly relief in 16 patients (80%), and mild relief in 2 patients (10%). Also 17 patients were able to walk freely (85%). Only one patient still had walking difficulty. No patient had skin reaction or side effect. The electrolytes and biochemical data were all within normal limits. Only 2 patients had the feeling of cold sweating after initial injection. We conclude that elcatonin is effective to relieve back pain in patients with osteoporosis, even they had associated compression fracture of the vertebral bodies.