- 期刊
Evidence for Up-Regulation of Estrogen Receptor mRNA in Chondrocytes of Early Osteoarthritic Rabbits
並列摘要
The purpose of this study was to investigate the alteration of estrogen receptor mRNA in an early stage of estradiol-induced osteoarthritic knees. After 3 weeks of intraarticular injections of estradiol benzoate to both knees in ovariectomized rabbits, the articular cartilages of femoral condyle and tibial plateau were harvested and pooled separately in each rabbit. The mRNA level of cytosolic estradiol receptor was determined by dot-blot analysis. The level was 2.5 fold higher in the femoral condyle cartilage of estradiol-treated rabbits than that in vehicle-treated rabbits. On the ogher hand, the mRNA level of estrogen receptors was almost nondetectable in the tibial plateau of either vehicle or estradiol-treated rabbits. It appeared that the mRNA of cytosolic estradiol receptor existed preferentially in the cartilage of femoral condyle, rather than in that of tibial plateau. Since a direct link of estrogen to the development of esteoarthritis in rabbit knees was demonstrated as early as 3 weeks, it is suggested that up-regulation of estrogen receptors in cartilage might correlate with the occurrence of osteoarthritis.
並列關鍵字
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