Bone Marrow-Derived, Cryo-Preserved Mesenchymal Progenitor Cells Are Able to Heal Segmental Bone Defects - A Rabbit Experiment

We studied the osteogenic ability of bone-marrow derived, cryo-preserved mesenchymal progenitor cells in rabbits. Ulnar shaft defect model was used in this study. Bone marrow progenitor cells were harvested from iliac crest aspira-tion. After the cells were separated from the bone marrow aspirate, they were cryo-preserved immediately without expansion. Six weeks later, the cells were injected into the defect side in the first experiment group. Autologous bone mar-row was aspirated from the iliac crest and was injected immediately into the defect side in the second experiment group. Animals were killed six and twelve weeks after the injection. Radiograhphic analysis, bone mineral density mea-surement and three-point bending tests were done to evaluate bone regenera-tion. The results showed that the osteogenic ability of bone marrow-derived pro-genitor cells was as good as fresh bone marrow injection and they were both effective in regenerating bone defects in comparison with the sham control group. Therefore, we conclude that bone marrow-derived, cryo-preserved mes-enchymal progenitor cells alone were able to heal segmental bone defects.

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