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Two-Stage Treatment of Late Chronic Infected Total Knee Arthroplasty Using an Antibiotic Impregnated Cement Spacer

雙期人工關節重建併用抗生素填塞之骨水泥以治療遲發性人工膝關節術後感染

並列摘要


This study was undertaken to evaluate the results of two-stage treatment of late chronic total knee arthroplasty (TKA) infection using an antibiotic-impregnated cement spacer. Twenty-nine knees in 29 patients with late chronic TKA infection were treated with debridement, component removal, insertion of an antibiotic-impregnated cement spacer with Steinmann pin fixation, and second-stage revision TKA. All patients followed individualized regimens of intravenous antibiotic therapy for 2 weeks and oral antibiotic therapy for at least 4 weeks. Follow-up averaged 72 months (range, 31-118 months). The average range of motion after second-stage surgery was 107° (range, 85°-135°), and the average Hospital for Special Surgery knee score was 89.4 (range, 74-93). The average visual analogue scale pain score was significantly improved. Two patients died after second-stage surgery owing to end-stage renal disease under hemodialysis. One patient had a recurrence of infection. The success rate was therefore 96.3% (26 of 27 patients). Use of a static antibiotic-impregnated cement spacer can eradicate chronic late TKA infection, facilitate second-stage surgery, reduce postoperative pain, improve function, and preserve maximum range of motion after second-stage surgery.

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