台灣嘉南地區居民血液中同半胱胺酸濃度與年齡及性別之相關性探討

Effects of Age and Gender on Mean Plasma Homocysteine Levels in Inhabitants of the Chianan Region of Taiwan

郭玫君(Mei-Chun Kuo) ； 陳志成(Chi-Cheng Chen) ； 鄭哲舟(Che-Chou Cheng) ； 吳明娟(Ming-Jiuan Wu) ； 邱可欣(Ko-Hsin Chiu) ； 林宜靜(Yi-Ching Lin) ； 楊竹茂(Jwu-Maw Yang)

《中華民國營養學會雜誌》 27卷2期 (2002/06) Pp. 84-91

https://doi.org/10.6691/JCNS.200206_27(2).0004

摘要

Recent studies have shown that elevated plasma total homocysteine (tHcy) is an independent risk factor for cardiovascular disease. In the study, 54 elderly volunteers(31 males, 23 females; mean age of 66.74 years) and 59 younger volunteers (31 males, 28 females; mean age of 19.23 years) were randomly selected from inhabitants of the Chianan region of Taiwan, and who did not have a history of cardiovascular diseases. Level of tHcy in plasma specimens drawn from volunteers were analyzed by high performance liquid chromatography (HPLC) with fluorescence detection. The mean levels of tHcy were 11.16 ± 2.94 μM and 5.76 ± 1.66 μM in the elderly and younger groups, respectively. Results of statistical analyses (Student’s t-test) using SPSS software indicated that the mean levels of tHcy in the elderly group was significantly higher than that of the younger group(p ＜ 0.01). In addition, in both groups, the mean level of tHcy of male subjects was significantly higher than that of female subjects (p ＜ 0.05). Finally, although the tHcy levels of most of the subjects involved in this study were below the cut point of 15.8 μM, we can not absolutely conclude that the risk of tHcy for cardiovascular diseases in Taiwanese people in negligible, since the number of participants in the study was rather small. However, the results of this study ban be an important reference for the further investigation of related issues.

關鍵字

同半胱胺酸 ； 年齡 ； 性別

並列摘要

Recent studies have shown that elevated plasma total homocysteine (tHcy) is an independent risk factor for cardiovascular disease. In the study, 54 elderly volunteers(31 males, 23 females; mean age of 66.74 years) and 59 younger volunteers (31 males, 28 females; mean age of 19.23 years) were randomly selected from inhabitants of the Chianan region of Taiwan, and who did not have a history of cardiovascular diseases. Level of tHcy in plasma specimens drawn from volunteers were analyzed by high performance liquid chromatography (HPLC) with fluorescence detection. The mean levels of tHcy were 11.16 ± 2.94 μM and 5.76 ± 1.66 μM in the elderly and younger groups, respectively. Results of statistical analyses (Student’s t-test) using SPSS software indicated that the mean levels of tHcy in the elderly group was significantly higher than that of the younger group(p ＜ 0.01). In addition, in both groups, the mean level of tHcy of male subjects was significantly higher than that of female subjects (p ＜ 0.05). Finally, although the tHcy levels of most of the subjects involved in this study were below the cut point of 15.8 μM, we can not absolutely conclude that the risk of tHcy for cardiovascular diseases in Taiwanese people in negligible, since the number of participants in the study was rather small. However, the results of this study ban be an important reference for the further investigation of related issues.

並列關鍵字

homocysteine ； age ； gender