富含n-3多元不飽和脂肪酸之藻油補充品對於使用化放療頭頸癌患者之影響－病例報告

The Effect of n-3 PUFA-rich Algal Oil Supplementation in a Head and Neck Cancer Patient During CCRT: Case Report

邱子涵(Tzu-Han Chiu) ； 蔡宛芮(Wan-Ruei Cai) ； 侯沂錚(Yi-Cheng Hou)

《台灣營養學會雜誌》 43卷2期 (2019/06) Pp. 47-56

https://doi.org/10.6691/NSJ.201906_43(2).0002

摘要

放射線與化療是常見之頭頸癌療程之一，放化療期間增加n-3多元不飽和脂肪酸（n-3 poly-unsaturated fatty acids, n-3 PUFAs）之攝取，可以幫助降低體內之發炎反應，素食來源之藻油富含n-3多元不飽和脂肪酸，本篇將討論藻油對接受合併化放療頭頸癌病患的影響。本個案為1位59歲女性，鼻咽癌第2期（cT1N1M0, stage II），接受放療合併化學治療。個案茹素多年。在營養師營養介入前，個案之白蛋白及C-反應蛋白指數皆屬於正常值間。個案因即將放化療，故給予化療期間營養注意事項衛教及n-3多元不飽和脂肪酸對於治療期間之影響，且願意使用藻油補充品。經營養介入後，個案之白蛋白指數維持正常，C-反應蛋白上升減少，減輕之體重小於文獻中之10%，顯示藻油能維持頭頸癌病患之整體營養狀況。

關鍵字

頭頸癌 ； 素食 ； 藻油 ； n-3多元不飽和脂肪酸

並列摘要

Radiotherapy and chemotherapy are common head and neck cancer regimens. Increasing the intake of n-3 polyunsaturated fatty acids (PUFAs) during radiotherapy and chemotherapy can reduce inflammation. Algal oil is a vegetarian product and is rich in n-3 PUFAs. We discuss the effect of algal oil supplementation in head and neck cancer patients during [?]continuous renal replacement therapy (CRRT). This case was a 59-year-old woman with stage II nasopharyngeal carcinoma (NPC) receiving radiotherapy and chemotherapy. She had been a vegetarian for many years. Before the dietitian's nutrition intervention, albumin and C-reactive protein (CRP) were in normal ranges. Before radiotherapy and chemotherapy, she agreed to receive nutritional education about the effects of n-3 PUFAs during chemotherapy and used a vegetarian source of an n-3 PUFA supplement. Following a sustained nutritional intervention, albumin remained in a normal range, the increase in CRP was reduced, and weight loss was less than 10% that described in the literature. This case report indicates that the algal oil supplementation can maintain the nutritional status in head and neck cancer patients during CRRT.

並列關鍵字

head and neck cancer ； vegetarian ； algal oil ； n-3 fatty acid