種子胜肽Lunasin抑制肥胖相關的發炎反應與乳癌進展

Seed peptide lunasin abates obesity-related inflammation and breast cancer progression

謝佳倩(Chia-Chien Hsieh)

《台灣營養學會雜誌》 44卷3期 (2020/09) Pp. 62-69

https://doi.org/10.6691/NSJ.202009_44(3).0001

摘要

非傳染性之慢性病因需長期的醫療照護且高發病率和死亡率，已成為21世紀的重要議題，飲食調節和良好生活習慣被認為是預防這些疾病的最佳策略。科學家除了了解食物中基本的營養作用外，更積極研究其它健康促進的益處。Lunasin是天然化合物中極具潛力的成分之一，為一種存在於大豆、小麥、大麥和其他種子中的天然胜肽，已被證實具有數種生物活性，包含抗腫瘤、抗發炎、抗氧化與調節膽固醇之功效。研究顯示過重和肥胖與數種慢性疾病有關，並且顯著影響多種癌症的發展，已成為當今食物充裕的世代之關鍵性議題，其中乳癌更是全球女性最容易好發的癌症之一，且與肥胖密切關連。在肥胖過程中通常伴隨著慢性與低度的炎症反應，免疫細胞的浸潤與發炎相關因子提供了有利於腫瘤生長的微環境。本論文簡述Lunasin的生物活性功能，並探討其在肥胖驅動的發炎反應與乳癌進展之研究。

關鍵字

抗發炎 ； 化學預防 ； 癌症 ； Lunasin種子胜肽 ； 肥胖

並列摘要

Noncontagious chronic diseases have turned into a critical issue in the 21st century, because of the long term of medication, high incidence and high mortality. The best strategy to prevent these diseases is good dietary habits and lifestyles. Beyond their primary nutritional effects, scientists are interested in the health benefits of natural compounds in daily diet. Seed peptide lunasin is considered as one of potential agents in natural plants, was found in soy, wheat, barley, and other seeds, and has been demonstrated multiple bioactivities, such as anti-carcinogenesis, anti-inflammation, anti-oxidation, cholesterol regulated properties. Overweight and obesity are associated with several chronic diseases development, especially cancers. A chronic and low-grade inflammatory response usually accompanied the obese process. Immune cells infiltration and inflammatory cytokines secretion provide a microenvironment that is conducive to tumor growth. Breast cancer is one of the most common cancers among women worldwide, and its cause is close to obesity. This review briefly summarized multiple bioactivities of lunasin, and focused on obesity-related inflammatory response and breast cancer progression.

並列關鍵字

Anti-inflammation ； Chemoprevention ； Cancer ； Lunasin ； Obesity