Changes of Cancer-antigen 125 (CA 125) by Use of the Amino-acid Based Peritoneal Dialysate in CAPD Patients

使用胺基酸為基礎的腹膜透析液對腹膜流出液中CA125濃度之影響

林士弼(Shih-Pi Lin) ； 陳鴻鈞(Hung-Chun Chen) ； 張哲銘(Jer-Ming Chang) ； 賴永勳(Yung-Hsiung Lai)

《Acta Nephrologica》 14卷4期 (2000/10) Pp. 328-328

並列摘要

Background Conventional peritoneal dialysis fluids are bioincompatible because of their hyperosmolality, low pH, high lactate and glucose concentration. High glucose concentration to glucose degradation products (GDPs), which are cytotoxic to peritoneal membrane. However, the amino acid-based PD fluid might cause less mesothelial damage.
Patients and Methods 17 Adults CAPD patients (11M/6F)_ who have received CAPD for at least 6 months with low serum albumin levels (＜3.7 g/dl) were enrolled. Diet was not specifically changed. They all received four-exchange CAPD treatment and amino acid dialysate was used as once daily substitute, given at the first or second exchange. Cancer antigen 125 (CA125) concentration of effluent dialysate were checked every 2 weeks for 3 months.
Results CA 125 levels were found to be increased in 50% (5/14), and decreased in 14% (2/14) of patients (range from 35 to 63%).
Conclusion These results reveal that once daily exchange with amino acid dialysate in stable PD patients increase CA125 level of effluent dialysate indicate that amino acid-based PD fluid cause less mesothelial damage. It may be considered more biocompatible than conventional PD soulution.