Clinical Analysis of Pheochromocytoma/Paraganglioma in Southern Taiwan

南台灣旳嗜鉻細胞瘤／副神經瘤：二十三位病例的臨床分析和其他腎上腺腫瘤

黃國清(Kuo-Ching Huang) ； 王明誠(Ming-Cheng Wang) ； 吳安邦(An-Bang Wu) ； 盧豐華(Feng-Hwa Lu) ； 曾進忠(Chin-Chung Tseng) ； 黃建鐘(Jeng-Jong Huang)

《Acta Nephrologica》 20卷3期 (2006/07) Pp. 166-174

摘要

Pheochromocytoma, albeit rare, is an important cause of secondary hypertension. Although potentially curable, it can be lethal if it goes unrecognized. We reviewed the medical charts of 145 patients with ICD-9 coded as adrenal tumors from 1988 to 2004. A total of 140 patients were enrolled in this study. Eighteen patients had Pheochromocytoma, and five patients had paraganglioma. Among these 23 Pheochromocytoma/paraganglioma patients, 13 cases had hypertension. A total of 12 received an operation and had no intra-operative mortality. Eleven patients became normotensive after operation. The other one, who was concomitant with diabetic nephropathy and chronic renal insufficiency, had persistent hypertension after operation and progressed to end-stage renal disease. Urinary levels of vanillylmandelic acid (VMA) were checked in 14 patients. Comparing the estimated tumor sizes with the urinary levels of VMA, larger masses had higher VMA levels (r=0.5668, P=0.0434). The Pheochromocytoma/paraganglioina had the variable clinical presentations and was a nearly curable hypertensive disease. Also, the urinary levels of VMA correlated with estimated tumor sizes.

關鍵字

腎上腺腫瘤 ； 嗜鉻細胞瘤 ； 副神經瘤 ； 高血壓 ； 香草杏仁酸VMA ； 腎上腺切除術

並列摘要

Pheochromocytoma, albeit rare, is an important cause of secondary hypertension. Although potentially curable, it can be lethal if it goes unrecognized. We reviewed the medical charts of 145 patients with ICD-9 coded as adrenal tumors from 1988 to 2004. A total of 140 patients were enrolled in this study. Eighteen patients had Pheochromocytoma, and five patients had paraganglioma. Among these 23 Pheochromocytoma/paraganglioma patients, 13 cases had hypertension. A total of 12 received an operation and had no intra-operative mortality. Eleven patients became normotensive after operation. The other one, who was concomitant with diabetic nephropathy and chronic renal insufficiency, had persistent hypertension after operation and progressed to end-stage renal disease. Urinary levels of vanillylmandelic acid (VMA) were checked in 14 patients. Comparing the estimated tumor sizes with the urinary levels of VMA, larger masses had higher VMA levels (r=0.5668, P=0.0434). The Pheochromocytoma/paraganglioina had the variable clinical presentations and was a nearly curable hypertensive disease. Also, the urinary levels of VMA correlated with estimated tumor sizes.

並列關鍵字

Adrenal tumor ； Pheochromocytoma ； paraganglioma ； hypertension ； vanillylmandelic acid VMA ； adrenalectomy