A 72-year-old mule patient on hemodialysis therapy was noted with persistent hypercalcemia and progressively developed abdominal distension. The abdominal echo revealed massive ascites, and computed tomographic (CT) scan showed multiple intraabdominal nodules. Abdominal malignancy was highly suspected. Subsequent studies showed that the chest film was free from pulmonary lesions, the hepatitis markers were negative for hepatitis B and C, and the serum intact parathyroid hormone level was low. All tumor markers surveyed were negative and no definite tumor mass was found although gastric malignancy was suspected by radiologist. Owing to the predominant monocytes without atypical cells in ascitic fluid, we started the empirical anti-TB therapeutic trial although no other evidence of TB was found. The abdominal distention and hypercalcemia improved soon. Follow-up abdominal CT scan revealed resolution of ascites and intraperitoneal nodules. Intraperitoneal TB was diagnosed according to the good response to anti-TB agents.