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Hypercalcemia Caused by Metachronous Metastases of Renal Cell Carcinoma in Uremia

尿毒症病人因腎細胞癌異時轉移而出現高血鈣症

摘要


腎細胞癌常現出莫測的臨床表現包括多種的腫瘤自分泌症候群以及異時轉移。在本文中,我們報導了一名長期接受血液透析的病人因腎細胞癌接受雙側腎及輸尿管切除術三年後,因異時骨骼轉移而出現急性的高血鈣症。腎細胞癌在透析病人的表現有別於一般病人而有獨特的表現。尿毒病人喪失了腎臟排泄鈣離子的能力,高血鈣可能是延遲轉移最先甚至是唯一的症兆。此病例說明了在併有腎細胞癌病史的透析病人若出現原因不明的高血鈣症,即使是在術後若干年後,仍有必要進一步排除腫瘤復發的可能性。

並列摘要


Renal cell carcinoma (RCC) is characterized by unpredictable clinical manifestations including paraneoplastic syndromes and metachronous metastases. We describe a hemodialysis patient presenting with acute progressive hypercalcemia from delayed bone metastases of RCC three years after bilateral nephroureterectomy. Because of the loss of renal excretion of excess calcium, hypercalcemia may be the first observed sign in dialysis patients with RCC. As hypercalcemia is not uncommon in the dialysis population, it is easy to overlook the sign of delayed recurrence of the malignancy. This case highlights the importance of screening for tumor recurrence in hemodialysis patients with hypercalcemia and previous RCC.

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