Renal cell carcinoma (RCC) is characterized by unpredictable clinical manifestations including paraneoplastic syndromes and metachronous metastases. We describe a hemodialysis patient presenting with acute progressive hypercalcemia from delayed bone metastases of RCC three years after bilateral nephroureterectomy. Because of the loss of renal excretion of excess calcium, hypercalcemia may be the first observed sign in dialysis patients with RCC. As hypercalcemia is not uncommon in the dialysis population, it is easy to overlook the sign of delayed recurrence of the malignancy. This case highlights the importance of screening for tumor recurrence in hemodialysis patients with hypercalcemia and previous RCC.