Negative Association of Occult Leptospirosis Infection and Chronic Kidney Disease in North Taiwan

BACKGROUND: The prevalence and incidence of end-stage renal disease are high in Taiwan. Acute leptospirosis infection often causes renal tubulointerstitial disease, but the association of occult leptospirosis and renal disease is unclear. The aim of this study is to define the possible association between occult leptospirosis infection and chronic kidney disease (CKD). METHODS: In this prospective observational cohort study, 371 patients with CKD and 100 residents without CKD in the same community were included. Microscopic agglutination test (MAT) was employed to detect occult leptospirosis. Both renal progression and microalbuminuria were also monitored during a follow-up period of 42 months. RESULTS: Low prevalence of positive MAT is found in normal and CKD subjects. There was no significant difference in amount of microalbuminuria between MAT positive and negative subjects (527.52 ± 125.18 vs. 728.2 ± 216.23, mg/day, P ＞ 0.05). Logistic analysis for CKD progression did not show different CKD progression between MAT positive and negative groups. CONCLUSION: The prevalent rates of positive MAT in normal and CKD subjects were similar. There was also no difference in microalbuminuria and CKD progression between MAT positive and negative subjects. Our findings suggested that occult leptospirosis might not be associated with development and progression of CKD in North Taiwan.

並列關鍵字

chronic kidney disease ； leptospirosis ； renal tubulointerstitial disease

參考文獻

Atkins RC. The epidemiology of chronic kidney disease. Kidney In 94 (suppl): S14-S18, 2005.

US Renal Data System: USRDS 2005 Annual Data Report. The National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Disease, Bethesda, MD, 2005.

Dirks JH, de Zeeuw D, Agarwal SK, Atkins RC, Correa-Rotter R, D'Amico G, et al. Prevention of chronic kidney and vascular disease: toward global health equity¡Xthe Bellagio 2004 Declaration. Kidney Int 98 (suppl): S1-S6, 2005.

Kuo HW, Tsai SS, Tiao MM, Yang CY. Epidemiological features of CKD in Taiwan. Am J Kidney Dis 49: 46-55, 2007.

Bharti AR, Nally JE, Ricaldi JN, Matthias MA, Diaz MM, Lovett MA, et al. Leptospirosis: a zoonotic disease of global importance. Lancet Infect Dis 3: 757-771, 2003.

延伸閱讀

Liao, Y. W., Hung, W. T., Chen, Y. M., Hsieh, C. W., Hsieh, T. Y., Chen, H. H., Lai, K. L., Tang, K. T., Lin, C. T., Tseng, C. W., Chou, Y. Y., Huang, W. N., & Chen, Y. H. (2019). Histopathological Characteristics of Lupus Nephritis: A 10-year Single Center Experience in Taiwan. Formosan Journal of Rheumatology, 33(1), 34-39. https://doi.org/10.6313/FJR.201909_33(1).0005
蔡崇煌、李怡慶、羅永杰、周俊德（2006）。Non-Alcoholic Fatty Liver Disease and Obesity-Associated Factors: A Study in a Regional Hospital in Mid-Taiwan。台灣家庭醫學雜誌，16(4)，215-225。https://doi.org/10.7023/TJFM.200612.0215
Lin, C. C., Chen, M. C., Hsieh, H. F., & Chang, S. C. (2013). Illness Representations and Coping Processes of Taiwanese Patients with Early-Stage Chronic Kidney Disease. The Journal of Nursing Research, 21(2), 120-128. https://doi.org/10.1097/JNR.0b013e3182921fb8
Wang, R. S., Chiou, C. C., Hsieh, K. S., Kau, C. K., Cheng, H. H., & Chiou, Y. H. (2004). Clinical and Laboratory Features of Juvenile-onset Systemic Lupus Erythematosus in Southern Taiwan. Formosan Journal of Rheumatology, 18(1&2), 11-18. https://doi.org/10.6313/FJR.2004.18(1-2).02
Chang, S. C., Su, C. H., Chou, W. H., Hwang, K. P., Chuang, Y. C., Chou, M. Y., Leu, H. S., Wang, F. D., Wang, J. T., Wang, L. S., Chen, S. C., Chien, L. J., Tseng, S. H., & Yen, J. J. (2009). Epidemiology of Nosocomial Clostridium difficile Disease in Taiwan. Epidemiology Bulletin, 25(3), 163-177. https://doi.org/10.6525/TEB.200903_25(3).0002

國際替代計量

Negative Association of Occult Leptospirosis Infection and Chronic Kidney Disease in North Taiwan

全文下載

主題瀏覽