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- OpenAccess
Outcomes of Monomicrobial Peritoneal Dialysis-Related Peritonitis Caused by Non-Pseudomonas Gram-Negative Pathogens
摘要
BACKGROUND: The causative microorganism of peritoneal dialysis (PD)-related peritonitis is an important determinant of patient and technique survival. This retrospective study aimed to investigate the outcomes of monomicrobial peritoneal dialysis-related peritonitis caused by non-Pseudomonas Gramnegative (NPGN) pathogens. METHODS: We analyzed the data of causative microorganisms and outcomes of monomicrobial PDrelated peritonitis in two medical centers in Tainan. The main outcome variables of PD-related peritonitis were the time to dialysate effluent white blood cells ＜ 100/mm^3, length of hospital stay, catheter removal/transfer to hemodialysis, and in-hospital mortality. RESULTS: 104 patients with 151 episodes of monomicrobial Gram-negative PD-related peritonitis were included for final analysis. The overall treatment failure rate was 21%. Escherichia coli and Klebsiella species were the two most common causative pathogens. The risk of peritoneal catheter removal and mortality in NPGN peritonitis was higher than that in Gram-positive peritonitis (40% vs. 10%, P ＜ 0.0001). Among patients with NPGN peritonitis, there was no significant difference between the group of Escherichia coli plus Klebsiella species and the group of other NPGN bacteria in improvement rate, time to dialysate effluent WBC ＜ 100/mm^3, and catheter removal/transfer to hemodialysis. CONCLUSION: This study demonstrated that the outcomes in NPGN peritonitis were significantly worse compared to those in Gram-positive peritonitis. Among patients with NPGN peritonitis, there was no significant difference between the group of E. coli plus Klebsiella species and the group of other Gramnegative bacteria in response to antimicrobial therapy, hospitalization management, and catheter removal/ transfer to hemodialysis.
延伸閱讀
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